INTRODUCTION Tumor-directed and immune-system-stimulating therapies are of special interest in cancer treatment. Here, we demonstrate the potential of parvovirus H-1 (H-1PV) to efficiently kill colorectal cancer cells and induce immunogenicity of colorectal tumors by inducing maturation of dendritic cells (DCs) alone and also in combination with cytostatic drugs in vitro. Using our cell culture...

Non-motile cilia are thought to be important determinants of the progression of many types of cancers. Our goal was to identify patterns of cilia gene dysregulation in eight cancer types (glioblastoma multiforme, colon adenocarcinoma, breast adenocarcinoma, kidney renal clear cell carcinoma, lung squamous cell carcinoma, lung adenocarcinoma, rectal adenocarcinoma, and ovarian cancer) profiled b...

Crohn's disease is not usually regarded as a premalignant state. Recent reviews of the literature1' 2 make scant reference to an association of regional enteritis with carcinoma. However, at the World Congress of Gastro-enterology, I958, Crohn observed that he had seen two cases of carcinoma of the small intestine co-existing with regional enteritis.3 Rare cases of carcinoma arising in patients...

aim : this study aims to investigate some clinical and pathologic factors associated with the prognosis of patients with colon and rectum cancers separately. background : colorectal cancer is the most common cancer of the digestive system and also the fourth cause of cancer-related deaths around the world. different studies indicate that survival of patients with colorectal cancer has improved ...

Metastasis to the primary thyroid carcinoma is extremely rare. We report here a case of colonic adenocarcinoma metastasis to medullary thyroid carcinoma in a 53-yr old man with a history of colon cancer. He showed a nodular lesion, suggesting malignancy in the thyroid gland, in a follow-up examination after colon cancer surgery. Fine needle aspiration biopsy (FNAB) of the thyroid gland showed t...

We have investigated the expression of the protooncogenes of the myc and ras family in HT29 cells and in three differentiated clonal cell lines derived from this colon carcinoma cell line. In contrast to the decrease in myc expression seen »lionleukemia cells are induced to differentiate, we have found no changes in expression of the myc gene family in differen tiated colon carcinoma cells. Ho...

The Lewis a antigen (Lea)- and Lewis b antigen (Leb)-active glycolipids and glycoproteins in normal colon mucosa, colon carcinoma tumors, and gastrointestinal tumor cell lines were studied by using monoclonal antibodies against Lewis determinants in solid-phase radioimmunoassay, chromatogram binding assay, and immunoprecipitation/PAGE. Lea-5 was a major component of the purified non-acid glycol...

Colon cancers are thought to be an inevitable result of aging, while testicular cancers are thought to develop in only a small fraction of men, beginning in utero. These models of carcinogenesis are, in part, based upon age-specific incidence data. The specific incidence for colon cancer appears to monotonically increase with age, while that of testicular cancer increases to a maximum value at ...

We have produced a monoclonal antibody CCOL1 that is cytotoxic at a titer of 1:20,000 using human sera as a complement source. CCOL1 reacts to the immunizing colon carcinoma line as well as to one other colon carcinoma line. However, it does not react with another colon adenocarcinoma line or with 28 other cultured tumor cells. It is noncytotoxic to lymphocytes, monocytes, granulocytes, RBC, an...

BACKGROUND To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas. METHODS Prognoses of 15 cases of UC-associated colonic carcinoma were compared with those of sporadic colon carcinoma cases, after which 75 cases of sporadic invasive adenocarcinom...