Campylobacter jejuni 81-176 lipooligosaccharide (LOS) is composed of two covalently linked domains: lipid A, a hydrophobic anchor, and a nonrepeating core oligosaccharide, consisting of an inner and outer core region. We report the isolation and characterization of the deepest rough C. jejuni 81-176 mutant by insertional mutagenesis into the waaC gene, encoding heptosyltransferase I that cataly...

This study examines the role of neutrophils (PMN) in the pathogenesis of the endothellal lesion induced by a single sublethal dose of endotoxin. It is intended to clarify whether the marginatlon of PMN on endothellum after endotoxin causes intimal injury or is a response to it. Neutropenic rabbits had mean PMN counts of 33/cu mm 72 hr after nitrogen mustard (HN2). They were heparinized and give...

Androgenic steroids in physiologic concenAnalysis of growth kinetics suggested that trotions were found to stimulate human increased granulopoiesis results from progranulopoiesis in vitro. Testosterone in liferation of committed granulocyte prehigh concentration, but probably within cursors in the marrow rather than stem-cell the range achievable after intensive treatactivation. ment, was found...

The fructan of Streptococcus mutans OMZ 176 was shown to have a levan structure by comparing the chromatographic mobilities of the saccharides produced by partial acid hydrolysis of ghe fructan and known levan and inulin. This was confirmed by using concanavalin A as a lectin in a double-diffusion gel technique.

Preliminary operating experience has been obtained with the Utah Anisotropy Detector. A muon detector located 486 hg cm underground at latitude 40° 37' N, it is designed to measure the sideral anisotropy of cosmic ray primaries whose median rigidity is about 1400 GV. Counting all angular bins in a 102° sector, we obtain a counting rate of 1.4 x 10/yr for the detector. The detector operates very...

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OBJECTIVE To characterize patients with chronic subdural hematoma undergoing surgery and to identify prognostic indicators. METHODS We conducted a retrospective analysis of patients diagnosed with chronic subdural hematoma (CSDH) undergoing surgical treatment. We analyzed: age, period from trauma to diagnostic imaging, pre and postoperative Glasgow coma scale, type of surgery, associated como...

There is now considerable evidence that spontaneous leukemias in mice are caused by C-type RNA viruses. These viruses appear to be capable of existing in the animal in an unexpressed form for many generations. In inbred mouse strains such as C58 and AKR, in which virus can be detected early in life, leukemia develops at high frequency in young animals (1, 2). In other strains such as BALB/c or ...

The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or loss of Phosphatase and Tensin homolog (PTEN). We have uncovered that growth factors binding to RTK...

We define a simple, explicit map sending a morphism f : M → N of pointwise finite dimensional persistence modules to a matching between the barcodes of M and N . Our main result is that, in a precise sense, the quality of this matching is tightly controlled by the lengths of the longest intervals in the barcodes of ker f and coker f . As an immediate corollary, we obtain a new proof of the alge...