BACKGROUND: Coffee arabica gayo leaf extract (Coffea L.) contains polyphenols (chlorogenic acid), flavonoids, saponins, tannins, and steroids which improved PI3K serum levels in rats type 2 diabetic rat. AIM: The purpose of the study was to determine effect Arabica Gayo Leaf Extract (C. on increased type-2 rat (Rattus norvegicus). METHODS: Thirty-five male Wistar with induced a combination feed...