نتایج جستجو برای: cochlear damage

تعداد نتایج: 241120  

2014
Naomi F. Bramhall Fuxin Shi Katrin Arnold Konrad Hochedlinger Albert S.B. Edge

The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound. Here, we show that supporting cells, which surround hair cells in the normal cochlear epithelium, differentiate into new hair cells in the neonatal mouse following ototoxic damage. Using lineage tracing, we sho...

Journal: :Journal of rehabilitation research and development 2008
Stephen J Rebscher Alexander Hetherington Ben Bonham Peter Wardrop David Whinney Patricia A Leake

The level of hearing rehabilitation enjoyed by cochlear implant (CI) recipients has increased dramatically since the introduction of these devices. This improvement is the result of continual development of these systems and the inclusion of subjects with less severe auditory pathology. Developments include advanced signal processing, higher stimulation rates, greater numbers of channels, and m...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Dan Bing Sze Chim Lee Dario Campanelli Hao Xiong Masahiro Matsumoto Rama Panford-Walsh Stephan Wolpert Mark Praetorius Ulrike Zimmermann Hanqi Chu Marlies Knipper Lukas Rüttiger Wibke Singer

BACKGROUND Accumulating evidence suggests that tinnitus may occur despite normal auditory sensitivity, probably linked to partial degeneration of the cochlear nerve and damage of the inner hair cell (IHC) synapse. Damage to the IHC synapses and deafferentation may occur even after moderate noise exposure. For both salicylate- and noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) rece...

Journal: :Acta medica Iranica 2012
Akram Pourbakht Azadeh Imani

We compared the extent of temporary threshold shift (TTS) and hair cell loss following high level 4 kHz noise exposure with those preconditioned with moderate level 1 and 4 kHz octave band noise. Fifteen Male albino guinea pigs (300- 350 g in weight) were randomly allocated into three groups: those exposed to 4 kHz octave band noise at 102 dB SPL (group 1, n=5); those conditioned with 1 kHz oct...

2017
Ahmed Khater Mohammad Waheed El-Anwar

Introduction  Recent advances in surgical techniques and electrode design have made residual hearing preservation during cochlear implantation (CI) possible, achievable, and desirable. Objectives  The objective of this study was to review the literature regarding methods used for hearing preservation during CI surgery. Data Synthesis  We performed a search in the LILACS, MEDLINE, SciELO, PubMed...

2013
Li Xia

Ototoxic models of animal represent an elemental tool in basic otological research. In the present study, using guinea pigs we compared cochlear lesions mediated via cisplatin applied in terms of two regimens: consecutive application alone and in combination with furosemide. The influences of furosemide alone were also assessed; it was observed to result in temporary hearing loss and reversible...

2014
Jennifer D. Gay Sergiy V. Voytenko Alexander V. Galazyuk Merri J. Rosen

Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but is reflected in a basic auditory processing task: detecting a tonal signal in a noise background, i.e., simultaneous masking. It is unresolved whether the mechanisms underlying simultaneous masking arise from the auditory periphery or from the central auditory ...

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