نتایج جستجو برای: coa synthase

تعداد نتایج: 106351  

Journal: :The Journal of nutritional biochemistry 2009
Nerea Pérez-Echarri Patricia Pérez-Matute Beatriz Marcos-Gómez Amelia Marti J Alfredo Martínez María J Moreno-Aliaga

The precise mechanisms by which omega-3 fatty acids improve fat metabolism are not completely understood. This study was designed to determine the effects of eicosapentaenoic acid (EPA) ethyl ester administration on the expression levels of several muscle, liver and adipose tissue genes involved in lipogenesis and fatty acid oxidation pathways. Male Wistar rats fed a standard diet (control anim...

Journal: :The Biochemical journal 1993
M D Greenspan H G Bull J B Yudkovitz D P Hanf A W Alberts

The beta-lactones L-659,699 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2- oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid) and its radioactive derivative 3H-L-668,411 (the 2,3-ditritiated methyl ester of L-659,699) inhibited a partially purified preparation of rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase with an IC50 of 0.1 microM. These compounds were also found to inhibit th...

Journal: :Journal of bacteriology 2001
N Smirnova K A Reynolds

The Streptomyces glaucescens beta-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII) initiates straight- and branched-chain fatty acid biosynthesis by catalyzing the decarboxylative condensation of malonyl-ACP with different acyl-coenzyme A (CoA) primers. This KASIII has one cysteine residue, which is critical for forming an acyl-enzyme intermediate in the first step of the process. Thre...

Journal: :Biochemistry 2009
Ping Li Sumit Chakraborty JoAnne Stubbe

Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis using C149 of PhaC with one PHB chain per PhaEC dimer. Two mechanisms for elongation have been proposed. The first inv...

2017

Submit Manuscript | http://medcraveonline.com Abbreviations: HR: Hypersensitive Response; SAR: Systemic Acquired Resistance; WIPK: Wound-Induced Protein Kinase; SIPK: Salicylic Acid-Induced Protein Kinase; TCA: Trichloroacetic Acid; 2-ME: 2-Mercaptoethanol; SDS: Sodium Dodecyl Sulphate; PMSF: Phenyl Methyl Sulfonyl Fluoride; 2DE: 2D Gel Electrophoresis; DTT: Dithiothreitol; aact: Acetyl-CoA C-A...

Journal: :Metabolism-clinical and Experimental 2021

Context In this study, we aimed to identify the determinants of mitochondrial dysfunction in skeletal muscle (SKLM) subjects with type 2 diabetes (T2DM), and evaluate effect pioglitazone (PIO) on SKLM proteome. Methods Two different groups adults were studied. Group I consisted 8 individuals normal glucose tolerance (NGT) T2DM, subjected proteome analysis by 2D-gel electrophoresis followed mass...

Journal: :Protein science : a publication of the Protein Society 2015
Namita Bhan Lingyun Li Chao Cai Peng Xu Robert J Linhardt Mattheos A G Koffas

A novel C17 resorcylic acid was synthesized by a structure-guided Vitis vinifera stilbene synthase (STS) mutant, in which threonine 197 was replaced with glycine (T197G). Altering the architecture of the coumaroyl binding and cyclization pocket of the enzyme led to the attachment of an extra acetyl unit, derived from malonyl-CoA, to p-coumaroyl-CoA. The resulting novel pentaketide can be produc...

2014
Zhubo Dai Beibei Wang Yi Liu Mingyu Shi Dong Wang Xianan Zhang Tao Liu Luqi Huang Xueli Zhang

Ginsenosides are the primary bioactive components of ginseng, which is a popular medicinal plant that exhibits diverse pharmacological activities. Protopanaxadiol, protopanaxatriol and oleanolic acid are three basic aglycons of ginsenosides. Producing aglycons of ginsenosides in Saccharomyces cerevisiae was realized in this work and provides an alternative route compared to traditional extracti...

Journal: :Pharmacological reviews 2010
Gary D Lopaschuk John R Ussher Jagdip S Jaswal

The central nervous system mediates energy balance (energy intake and energy expenditure) in the body; the hypothalamus has a key role in this process. Recent evidence has demonstrated an important role for hypothalamic malonyl CoA in mediating energy balance. Malonyl CoA is generated by the carboxylation of acetyl CoA by acetyl CoA carboxylase and is then either incorporated into long-chain fa...

Journal: :Journal of bacteriology 2006
Helge B Bode Michael W Ring Gertrud Schwär Reiner M Kroppenstedt Dale Kaiser Rolf Müller

Isovaleryl-coenzyme A (IV-CoA) is the starting unit for some secondary metabolites and iso-odd fatty acids in several bacteria. According to textbook biochemistry, IV-CoA is derived from leucine degradation, but recently an alternative pathway that branches from the well-known mevalonate-dependent isoprenoid biosynthesis has been described for myxobacteria. A double mutant was constructed in My...

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