Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Yeast has long been a popular model organism for biomedical research. In the current study, a weighted gene co-expression network analysis algorithm was applied to construct a gene co-expression network in Saccharomyces cerevisiae. Seventeen stable gene co-ex...

Modular targeting is promising in drug research at the network level, but it is challenging to quantificationally identify the precise on-modules. Based on a proposed Modudaoism (MD), we defined conserved MD (MDc) and varied MD (MDv) to quantitatively evaluate the conformational and energy variations of modules, and thereby identify the conserved and discrepant allosteric modules (AMs). Compare...

In multiplierless finite impulse response (FIR) filters, the product accumulation block (PAB) could be major contributor to hardware complexity, especially for high-order filters. this paper, an optimization scheme where constant multiplication and PAB are jointly optimized at bit-level is proposed minimize complexity. joint optimization, multiple multiplications (MCM) rearranged into several M...

Feathers are complex assemblages of multiple morphological innovations. Recent research on the development and evolution of feathers has produced new insights into the origin and diversification of the morphological innovations in feathers. In this article, I review and discuss the contribution of three different factors to the evolution of morphological innovations in feathers: feather tubular...

We define a cotriple (co)homology of crossed modules with coefficients in a π1-module. We prove its general properties, including the connection with the existing cotriple theories on crossed modules. We establish the relationship with the (co)homology of the classifying space of a crossed module and with the cohomology of groups with operators. An example and an application are given.

Recall that an algebraic module is aKG-module that satisfies a polynomial with integer coefficients, with addition and multiplication given by direct sum and tensor product. In this article we prove that non-periodic algebraic modules are very rare, and that if the complexity of an algebraic module is at least 3, then it is the only algebraic module on its component of the (stable) Auslander–Re...

In this paper we first introduce a new multiplication on triangular Banach algebras. Then we study their Arens regularity as well as their topological centers . In this paper we first introduce a new multiplication on triangular Banach algebras. Then we study their Arens regularity as well as their topological centers . In this paper we first introduce a new multiplication on triangular Banach ...

Accumulated transcriptome data can be used to investigate regulatory networks of genes involved in various biological systems. Co-expression analysis data sets generated from comprehensively collected transcriptome data sets now represent efficient resources that are capable of facilitating the discovery of genes with closely correlated expression patterns. In order to construct a co-expression...

Co-expression modules are groups of genes with highly correlated expression patterns. In cancer, differences in module activity potentially represent the heterogeneity of phenotypes important in carcinogenesis, progression, or treatment response. To find gene expression modules active in breast cancer subpopulations, we assembled 72 breast cancer-related gene expression datasets containing ∼5,7...

The analysis of the mutational landscape of cancer, including mutual exclusivity and co-occurrence of mutations, has been instrumental in studying the disease. We hypothesized that exploring the interplay between co-occurrence, mutual exclusivity, and functional interactions between genes will further improve our understanding of the disease and help to uncover new relations between cancer driv...