Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) or aquaporin 4 (AQP4-IgG) are associated with CNS inflammatory disorders. We directly compared MOG35-55-induced experimental autoimmune encephalomyelitis exacerbated by MOG- and AQP4-IgG (versus isotype IgG, Iso-IgG). Disease severity was highest after MOG-IgG application. administration increased disease incidence Iso-IgG. Inflammator...

Abstract Non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase rearrangement (ALK+) is known to have a high propensity form brain metastases (BrM), over 50% of ALK+ patients developing BrM despite effective ALK tyrosine inhibitor (TKI) therapy central nervous system (CNS) activity. Pharmacokinetic (PK) data from other CNS-active TKIs suggested that there may be differences in drug ...

Abstract We aimed to evaluate SIGLEC1 (CD169) as a biomarker in multiple sclerosis (MS) and Neuromyelitis optica spectrum disorder (NMOSD) the presence of + myeloid cells demyelinating diseases. performed flow cytometry-based measurements expression on monocytes 86 MS patients, 41 NMOSD patients 31 healthy controls. Additionally, we histologically evaluated acute chronic brain lesions well othe...

A 38-year-old man admitted with headache, left paresis and bilateral sensorineural hearing loss. Neuroimaging showed a peripheral frontal tumor with hyperintensity on T1WI and bilateral internal auditory canal (IAC) lesions. (Figures 1, 2 and 3). The presence of hyperintensity on T1WI, without fat or hemorrhage should direct for lesions containing melanin1. Resection of the frontal tumor diagno...

Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective ...

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder that frequently involves the central nervous system (CNS). We compared the clinical characteristics, treatment, and prognosis of patients with HLH according to the degree of CNS involvement. METHODS The clinical manifestations, initial laboratory data, treatment, and outcomes for 50 patients diagnosed with HLH ...

CNS-resident cells, in particular microglia and macrophages, are a source of inflammatory cytokines during inflammation within the CNS. Expression of IL-23, a recently discovered cytokine, has been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE) in mice. Expression of the p40 subunit of IL-12 and IL-23 by microglia has been shown in situ and in vitro,...

Proteins characteristic of growing axons often fail to be induced or transported along axons that have been interrupted far from their cell bodies in the adult mammalian CNS. Here, we inquire whether long axons in the mammalian CNS can support efficient axonal transport and deposition of one such protein, GAP-43, when the protein is induced in neuron cell bodies. We have used immunocytochemistr...

Multiple sclerosis (MS) is predominantly an immune-mediated disease of the central nervous system (CNS) unknown etiology with a possible genetic predisposition and effect certain environmental factors. It generally accepted that begins autoimmune inflammatory reaction targeting oligodendrocytes followed by rapid depletion their regenerative capacity subsequent permanent neurodegenerative change...

BACKGROUND AND PURPOSE Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disorder of the CNS and an animal model of multiple sclerosis. We used high-field MR microscopy at 17.6 T to image spinal cord inflammatory lesions in the acute stage of chronic relapsing rat EAE. We sought to compare lesions detected on MR imaging with histopathologic findings and to quantif...