Although virus-specific CD4(+) T cells have been characterized extensively in latently infected individuals, it is unclear how these protective T-cell responses develop during primary virus infection in humans. Here, we analyzed the kinetics and characteristics of cytomegalovirus-specific (CMV-specific) CD4(+) T cells in the course of primary CMV infection in kidney transplant recipients. Our d...

Cytomegalovirus (CMV)-associated diseases remain a major problem in transplant recipients. Early diagnosis is critical. Presentation of early CMV colitis can be mild and nonspecific in transplant recipients. Although serology is helpful in the diagnosis, sometimes it is inadequate. Because the endoscopic features of CMV colitis are specific, colonoscopy facilitates the histopathologic examinati...

BACKGROUND Cytomegalovirus is highly prevalent virus and usually occurs in immunocompromised patients. The pathophysiology and treatment of inflammatory bowel disease often induce a state of immunosuppression. Because this, there are still doubts and controversies about the relationship between inflammatory bowel disease and cytomegalovirus. AIM Evaluate the frequency of cytomegalovirus in pa...

It has long been textbook knowledge that in most patients an infective illness precedes the development of the GuillainBarré syndrome (GBS). About two thirds of patients report symptoms of an upper respiratory tract or gastrointestinal tract infection predating the disease by 1–4 weeks. Many diverse infectious agents have been incriminated as triggers of this acute polyradiculoneuropathy but on...

Cytomegalovirus (CMV) is a well-known opportunistic infection in immunocompromised hosts (1, 2). Cutaneous CMV infection has rarely been described and has variable clinical presentations (1–3), especially in patients with autoimmune bullous disease. A 76-year-old man presented with a 1-month history of multiple vesicles and erosions. A diagnosis of pemphigus vulgaris was made by histopathology ...

BACKGROUND Congenital cytomegalovirus (cCMV) infection contributes to considerable long-term sequelae in neonates and children all over the world. The association between viral genotypes and severity of clinical cytomegalovirus (CMV) infection is yet to be defined. The objective of this study was to find the impact of active CMV infection during pregnancy and the clinical significance of genoty...

A 30-year-old man was admitted because of febrile respiratory infection and confusion. A lumbar puncture revealed mild pleocytosis and elevated protein. Continuous conjugate eye oscillations in horizontal, rotatory, and vertical direction and diffuse myoclonus were observed (figure; see video on the Neurology Web site at www.neurology.org). Cytomegalovirus (CMV) encephalitis was diagnosed on th...

The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in so...

Dear Editor, The recent report by Kamel et al. [1] on primary cytomegalovirus infection in pregnant women is very interesting. The authors noted that ‘women who were IgM positive had no primary CMV infection in the index pregnancy as evidenced by the high CMV IgG avidity testing’ [1] . In fact, the usefulness of the IgG avidity test was previously reported by Seo et al. [2] , who noted that thi...

Abstract. We report here a 35 year-old immunocompetent male, with a fulminantly lethal diffuse alveolar hemorrhage caused by CMV pneumonia. The patient was admitted with fever, rust colored sputum and exertional dyspnea. A chest x-ray revealed bilateral alveolar infiltration in a butterfly pattern. Bronchoalveolar lavage (BAL) was performed which revealed alveolar hemorrhage. Microscopic findin...