We examined the interaction of complement component C3 with surface molecules on Trypanosoma cruzi. Five- to six-fold more C3 was bound to epimastigotes (Epi) than to metacyclic trypomastigotes (CMT) of strain M88. Epi and CMT were surface iodinated, then incubated in C8-deficient serum, and detergent lysates were applied to anti-C3 antibody that had been coupled to Sepharose. We found that 9.2...

Charcot-Marie-Tooth (CMT) disease is a well-known neural or spinal type of muscular atrophy. It is the most familiar disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN). The disease was discovered by three scientists several years ago. Several genes are involved as the causative agents for the disease. Hundreds of causative mutations have been found and ...

BACKGROUND Mutations in the GARS gene have been identified in a small number of patients with Charcot-Marie-Tooth disease (CMT) type 2D or distal spinal muscular atrophy type V, for whom disease onset typically occurs during adolescence or young adulthood, initially manifesting as weakness and atrophy of the hand muscles. The role of GARS mutations in patients with inherited neuropathies in Tai...

BACKGROUND & AIMS Walled-off pancreatic necrosis (WOPN), a complication of severe acute pancreatitis (SAP), can become infected, obstruct adjacent structures, and result in clinical deterioration of patients. Patients with WOPN have prolonged hospitalizations, needing multiple radiologic and medical interventions. We compared an established treatment of WOPN, standard percutaneous drainage (SPD...

[Purpose] The purpose of this study was to analyze and compare electrophysiological characteristics observed in nerve conduction studies (NCS) of chronic inflammatory demyelinating polyneuropathy (CIDP) and Charcot-Marie-Tooth disease type 1 (CMT 1). [Subjects] A differential diagnosis of acquired and congenital demyelinating neuropathies was based on a study of 35 patients with NCS-confirmed C...

Context: To measure central macular thickness (CMT) in diabetic patients after instilling intracameral dexamethasone at the end of cataract surgery and compare this measure with control group. Design: Prospective case-control study. Participants: 100 eyes of 100 diabetic patients undergoing cataract extraction. Methods: 50 eyes received intracameral dexamethasone 0.4mg/0.1ml at the end of surge...

The aim of this study to determine the Th1/Th2 cytokine balance in milk according bacterial species that cause subclinical mastitis cows. California Mastitis Test (CMT) was applied selected cows were divided into four groups: with negative CMT (n = 45); Escherichia coli (E. coli) group included only E. growing CMT-positive samples Streptococcus agalactiae (S. agalactiae) S. Staphylococcus aureu...

BACKGROUND Thymidine kinase 1 (TK1) is a deoxyribonucleic acid (DNA) precursor enzyme and a proliferation biomarker used for prognosis and treatment monitoring of breast cancer in humans. The aim was to determine if serum thymidine kinase 1 (sTK1) activity and sTK1 protein levels in dogs with mammary tumors could be useful in veterinary medicine. RESULTS Serum samples from 20 healthy dogs and...

Convective momentum transport (CMT) plays a central role in interactions across multiple space and time scales. However, because of the multiscale nature of CMT, quantifying and parameterizing its effects is often a challenge. Here a simple dynamic model with features of CMT is systematically derived and studied. The model includes interactions between a large-scale zonal mean flow and convecti...

PURPOSE To evaluate diurnal variations in intraocular pressure (IOP), central corneal thickness (CCT), and macular and retinal nerve fiber layer (RNFL) thickness in diabetic patients and normal individuals. METHODS This study included 11 diabetic patients with macular edema and 11 healthy individuals. IOP, CCT, and macular and RNFL thickness were measured every 3 hours on a single day between...