El presente trabajo busca comprobar empíricamente la hipótesis de curva medioambiental Kuznets (CMK) en las emisiones dióxido carbono (CO₂) y óxido nitroso (N₂O) durante el periodo 1990-2012 para 217 economías, utilizando base datos del Banco Mundial. Se realizó un modelo panel bajo tres alternativas (efectos fijos, efectos aleatorios primeras diferencias). Los resultados obtenidos muestran que...

Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to also COVID-19 severity. Here, we show a distinct mechanism by which N protein promotes NLRP3 inflammasome activation induce hyperinflammation. facilitates maturation proinflammatory cytokines and induces cultured cells mice. Mechanis...

Ceza muhakemesi sisteminde yapılan majör değişikliklerin, uygulamada gerek sistemin diğer müesseseleri ile maddi ceza hukuku kurumlarıyla çelişmesi oldukça muhtemeldir. Seri muhakeme usulünün tatbik edilmeye başlanmasıyla birlikte birçok tartışma gündeme gelmiş ve bu usul, ilkeleri hâkim/savcı konumu gibi açıdan ele alınmıştır. Bahsi geçen tartışmalardan bir tanesi de suçların, zincirleme şekil...

OBJECTIVE To assess the effect of caspase 3 inhibition, in the expression of intracellular antigens induced by apoptosis. MATERIAL AND METHODS Skin explants of neonatal Balb/c mice were used to assess the autoantigen expression. Skin was obtained by punch biopsies, tissues were cultured in DMEM; cell death was induced by chemicals and assessed by TUNEL. The expression of La, Ro, Sm, RNP, Caja...

Bcl-2 family proteins and interleukin-1-beta converting enzyme/Caenorhabditis elegans cell death gene-3 (ICE/CED-3) family proteases (caspases) represent the basic regulators of apoptosis. However, the precise mechanism by which they interact is unclear. In this study, we found that gamma-radiation-induced apoptosis of leukemia cells was associated with activation of multiple caspases and bax u...

Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leukemia cell lines, including TF-1, U937, CMK-1, HL-60, and Mo7e. TF-1 cells unde...

Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent chemopreventive activity against colon, lung, and breast cancers. In this study, we show that at pharmacological concentrations (1 to 3 mmol/L) sodium salicylate (Na-Sal) can potently induce programmed cell death in several human myeloid leukemia cell lines, including TF-1, U937, CMK-1, HL-60, and Mo7e. TF-1 cells unde...

Ceza Muhakemesi Kanununun 148. maddesinde ifade alma ve sorguda yasak usuller sayılmış; bu tür usullerle elde edilen ifadelerin rıza verilmiş olsa dahi delil olarak kabul edilmeyeceği belirtilmiştir. Söz konusu hükümde sayılan usullerin birçoğunun ne anlama geldiği içeriğinin nasıl doldurulması gerektiği kendiliğinden anlaşılmakla birlikte, aynı hususun aldatma için söylenemeyeceği açıktır. Zir...