Abstract Traditional chemotherapy remains the primary cancer treatment, but it shows low enrichment and non-specificity. Hence, we have designed a multifunctional nanocarrier based on glutathione (GSH)-responsive mesoporous silica nanoparticles (MSNs). Firstly, disulfide bonds were linked surface of silica. Then, doxorubicin (DOX) chlorin e6 (Ce6) co-loaded into pores. Finally, carboxymethyl ch...

Self-assembled molecular nanoconstructs with controllable physical, chemical, and biological properties represent one of the most versatile platforms for drug delivery. Above their critical micelle concentrations (CMCs), linear, branched, and hyperbranched amphiphilic block copolymers can assemble into thermodynamically stable supramolecular structures of different sizes, morphologies, and prop...

The Knowledge Environment for Collaborative Science (KnECS) is an open source informatics toolkit designed to enable knowledge grids that interconnect science communities, unique facilities, data, and tools. KnECS features a web portal with team and data collaboration tools, lightweight federation of data, provenance tracking, and multi-level support for application integration. We identify cap...

Critical micelle concentrations (CMCs) of cationic surfactant (alkyltrimethylammonium bromides, CnTABr, where n = 10, 12, 14, 16 and 18), and a bile salt sodium cholate (NaC) were determined from surface tension, conductance and dye solubilization methods, while of their equimolar mixtures from surface tension and dye solubilization methods. The interaction parameter (beta) obtained from analys...

One way to speed up the algorithm configuration task is to use short runs instead of long runs as much as possible, but without discarding the configurations that eventually do well on the long runs. We consider the problem of selecting the top performing configurations of the Conditional Markov Chain Search (CMCS), a general algorithm schema that includes, for examples, VNS. We investigate how...

This report summarizes this quarters accomplishments of the SciDAC CoG Kit project funded through the Department of Energy MICS program under grant number FWP #56825. The highlights of this semester include the collaboration with other SciDAC projects such as the DOE Science Grid, CMCS, and OGSA. All of these projects reuse components developed and designed by the CoG Kit project. Additionally,...

In this paper, micromechanical constitutive models are developed to predict the tensile and fatigue behavior of fiber-reinforced ceramic-matrix composites (CMCs) considering matrix fragmentation closure. Damage fragmentation, interface debonding, fiber’s failure considered in analysis response, closure, debonding repeated sliding hysteresis response. Relationships between established. Experimen...

Laser-induced graphene (LIG) has aroused a wide range of research interests ranging from micro-nano energy devices to the Internet Things (IoT). Nevertheless, non-degradability most-used synthetic polymer carbon sources poses serious threat environment. In this work, ecofriendly chitosan-based derivatives, including carboxymethyl chitosan (CMCS), oligosaccharide, and hydrochloride, are successf...

In designing, implementing, and evaluating distributed group support, it is necessary to consider the organisational considerations that affect the nature of support required for distributed work environments. This paper describes some of the challenges facing organisations using distributed group support and explores alternative approaches for researching these it concludes with a multi-discip...