With the availability of a method of purifying plasminogen from human Fraction IIL8 the therapeutic use of this enzyme in thrombotic conditions became a distinct possibility. Before attempting the clinical use of purified plasminogen, however, it appeared advisable to investigate the reporte that the enzyme responsible for the fibrinolytic activity can be separated from the agent producing prot...

Objective—A splice variant of fibrinogen, , has an altered C-terminal sequence in its gamma chain. This A/ fibrin is more resistant to lysis than A/ A fibrin. Whether the physical properties of and A fibrin may account for the difference in their fibrinolysis rate remains to be established. Methods and Results—Mechanical and morphological properties of cross-linked purified fibrin, including pe...

The rural and marginal people of Bangladesh are deprived of modern treatment facilities and hence greatly depend on medicinal plants. Besides, the higher cost and toxicity of synthetic drugs drives scientists towards search for natural source of medication for a number of diseases. Cost-effectiveness, easy availability and fewer side effects are making the herbal medicine more popular both amon...

PURPOSE A diet rich in berries is believed to play a distinct role in the prevention of metabolic diseases associated with obesity. So far, there have been no published clinical observations evaluating the influence of Aronia melanocarpa on hemostasis. The aim of our study was to investigate the effects of A. melanocarpa extract (AM) supplementation on platelet aggregation, clot formation, and ...

BACKGROUND AND PURPOSE We compared the activity of a new long-half-life, fibrin-specific tissue-type plasminogen activator (TPA) variant with that of wild-type TPA in rabbit models of embolic stroke and peripheral bleeding. METHODS In the embolic stroke model. TPA-induced clot lysis is followed by continuous monitoring of a radiolabeled clot lodged in the middle cerebral artery. Twenty-four h...

OBJECTIVE Among plasma proteins, fibrinogen represents a major target of oxidative modifications. In patients with post-acute myocardial infarction (6 months after the acute event), fibrinogen oxidation-induced carbonyls and fibrinogen function were estimated using in vitro and ex vivo approaches. Fibrinogen structural features and clot architecture were also explored. APPROACH AND RESULTS In...

BACKGROUND Iminodiacetic acid (IDA) derivatives can be used as ligands to form complexes with technetium, with potential application as hepatobiliary diagnostic agents. The aim of this study was to synthesize five novel IDA derivatives and to compare their effects on plasma haemostasis with clinically approved ligands for technetium complexation. METHODS The influence of synthesized IDA deriv...