OBJECTIVES Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. MATERIALS AND METHODS Fourteen analogs of 2-substituted phthalimide pharmacophore were synthesized and then were evaluated for the anticonvulsant activities in pentyl...

PURPOSE To evaluate clinical outcomes, quality-adjusted life years (QALY), cost effectiveness and cost utility associated with VNS therapy in children with refractory epilepsy in a developing country. METHODS Retrospective review of all children who underwent VNS implantation at King Abdullah University Hospital and Jordan University Hospital in Jordan. RESULTS Twenty eight patients (16 mal...

This study aimed to determine the post-ictal prolactin (PL) response in different types of seizures and seizure-like events in children, and correlate with the post-ictal duration. Patients were divided into group I (generalized tonic-clonic seizures, complex partial seizures or simple partial seizures), group II (febrile convulsions) and group III (conditions mimicking seizures). Group IV cons...

BACKGROUND According to the literature, generalized seizure as a presenting sign of stroke is rare, and in the reported cases it was accompanied by a focal neurological deficit. Presentation of a small ischemic atherothrombotic brain infarction with convulsive generalized seizure is very rare. METHODS We reported a patient with acute small ischemic atherothrombotic infarction associated with ...

Kindling, a sub threshold chemical or electrical stimulation, increases seizure duration and enhances accompanied behavior until it reaches a sort of equilibrium state. The present study aimed to explore the effect of curcumin on the development of kindling in PTZ kindled rats and its role in apoptosis and neuronal damage. In a PTZ kindled Wistar rat model, different doses of curcumin (100, 200...

A 79-year-old female suffered a prolonged, tonic–clonic seizure, sustaining bilateral comminuted fractures of the humeral heads as a consequence. The fractures were managed conservatively under orthopaedic supervision. Six months post-injury, abduction of the left and right arms is to only 30° and 45°, respectively. She is no longer capable of living independently and is awaiting long-term care...

Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by deliverin...

Introduction: Olive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ. Methods: In this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg ...

Clonic and tonic seizure-like movements of the extremities were observed during induction of anaesthesia with sevoflurane in a 9-yr-old girl. The tonic movements were associated with respiratory alkalosis and were not abolished by an i.v. injection of thiamylal 75 mg. Arterial pressure, heart rate and body temperature remained normal during the episode. Ventilation was assisted easily and then ...

The aim of this study was to determine the eff ect of 7-nitroindazole (7-NI – a preferential neuronal nitric oxide synthase inhibitor) on the protective action of oxcarbazepine (OXC) and vigabatrin (VGB) – two newer antiepileptic drugs (AEDs) against pentylenetetrazole (PTZ)-induced seizures in mice. The clonic seizure activity in mice was evoked by subcutaneous injection of PTZ (100 mg/kg) and...