BACKGROUND Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. METHODS We report on a 42-year-old woman, a process operator in a chemical factory, who developed work-related symptoms of rhinitis and asthma upon exposure to piperazine citrate. She remained symptom free during holidays and days off work. RESULTS Skin prick test with p...

Oligospermia in an otherwise clinically normal man, is one of the commonest conditions encountered in an infertility clinic. Medical management of oligospermia lags far behind expectations, and is still in an experimental stage. Efforts have been made to improve the semen picture of patients with the administration of hormones like testosterone, gonadotrophins or the ovulatory drug, Clomiphene ...

A young male who presented with isolated bihormonal gonadotrophin deficiency is described, Basal levels of LH and FSH were low and there was no response to clomiphene citrate or LHRH. The remaining anterior pituitary function was intact. The administration of a combination of human menopausal gonadotrophin and human chorionic gonadotrophin caused testicular maturation with spermatogenesis and f...

.. Objective: To compare effectiveness of clomiphene alone and in combination with metformin in terms of conception rate in patients presenting with polycystic ovary syndrome. Study Design: Randomized clinical trail. Place and duration of study: Department Obstetrics and Gynecology Unit I, Nishtar Hospital Multan, 6 months from 12th September 2009 to 11th March 2010. Methodology: Primary subfer...

We described 59-year-old men with history of secondary/tertiary hypogonadism, without primary hypothyroidism, elevated prolactin or hemochromatosis structurally intact hypothalamo- hypophyseal (HT-HP) axis who was diagnosed in 2017. He treated by different physicians Testosterone intramuscular injections, hCG injections and combination FSH injections. The patients wanted to have another child t...

428 receptors than the myometrium4. However, in younger women, besides its agonist action, these drugs may also block the estrogen receptors in the hypothalamus leading to intense output of gonadotrophins which lead to ovarian stimulation and growth of myoma. An increase in cervical and endometrial polyps with neoplastic change in the endometrium has been reported. The potential for similar pro...