Correspondence: Thomas G. Roberts, Jr., M.D., Farallon Capital Management, L.L.C., One Maritime Plaza, ite , an Francisco, Cali ornia . Mail: troberts arcap.com Recei ed Ma , accepted or p blication J ne , . lphaMed Press . http: d doi.org . theoncologist. . Decades o p blic and pri ate in estment in cancer biolog research has led to an enhanced nderstanding o the ndamental genetic changes that...

We appreciate the recent Perspective from Nicholson and Formea (1 ) because it allows us to clarify the role of Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for clinicians. CPIC publishes genotype-based drug therapy guidelines to help clinicians understand how genetic test results could be used to optimize drug therapy. The underlying assumption for CPIC guidelines is t...

The problems of precise clinical thermometry are enormous, and, because the degree of sensitization to ionizing radiation is strongly dependent on temperature and time at temperature, it is important that this problem be solved in a practical way. In lieu of accurate temperature-recording methods, it is imperative that any clinical treatment regimens which utilize heating be with temperatures w...

Literature on eco-parks and eco-clusters has emphasized the opportunities for the coupling of local economic development and sustainability, going beyond firms’ green strategies to include also supply chains and local networks of firms. Studies have described the conditions and policies for the development of new sustainable economic activities in specific areas based on the industrial ecology ...

Monoamine Oxidase Inhibitors DEAR SIR, Dr Pare's article on †̃¿ The Present Status of Monoamine Oxidase Inhibitors' is one of a genre that marks the renaissance of these drugs (Murphy et al, 1984; White & Simpson, 1985). This is understandable given that the †̃¿ second generation' compounds are less exciting than hoped, that early use of phenelzine was often with inadequate dosage and that im...

s+%26+Virtual+Meeting/Abstracts?&vmview;=abst_detail_view&confID;=47&abstractID;=33225; cited January19, 2009]47. Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treat-ment in patients with cytokine-refractory metastatic renal-cellcancer: a phase ii study. lancet Oncol 2007;8:975–84.48. Hutson TE, Davis ID, Machiels JP, et al. Pazopanib(GW786034) is active in metast...

In this issue of Value in Health, Thompson1Thompson D. Replication randomized, controlled trials using real world data: what could go wrong?.Value Health. 2021; 24 (In Press)Abstract Full Text PDF PubMed Scopus (5) Google Scholar reviews the merits and potential pitfalls efforts to replicate randomized (RCTs) real-world data (RWD). We agree with much content article but disagree author’s primar...

The novel antineoplastic drug taxol has been shown to be active clini cally against several types of human tumors. With improvement in treat ment strategy and the number of long-term survivors increasing, a ques tion that needs to be addressed is the potential carcinogenic effect of the treatment in the induction of second malignancies. We show here that when tested using an in vitro assay for ...

Chronic obstructive pulmonary disease (COPD) is the commonest indication for domiciliary non-invasive ventilation (NIV) in Europe. However, there is a paucity of evidence to support its use. A number of short-term randomised controlled trials (RCTs) failed to show any consistent benefit from NIV. In a crossover study comparing 3 months of bilevel ventilation plus long term oxygen therapy (LTOT)...

2466. Sorror, M.L., Storer, B.E., Sandmaier, B.M., Maris,M., Shizuru, J., Maziarz, R., Agura, E., Chauncey, T.R., Pulsipher, M.A., McSweeney, P.A., Wade, J.C., Bruno, B., Langston, A., Radich, J.,Niederwieser, D., Blume, K.G., Storb, R. & Maloney, D.G. (2008) Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic celltranspla...