A critical limitation of bioorthogonal click chemistry for in vivo applications has been its low reaction efficiency due to the pharmacokinetic barriers, such as blood distribution, circulation, and elimination in living organisms. To identify key factors that dominate the efficiency of click chemistry, here a rational design of near-infrared fluorophores containing tetrazine as a click moiety ...

The Click Modular Router provides a flexible platform for protocol development and testing. Integrating the Click Modular Router with a network simulator offers the advantage of bringing this flexibility into a simulation framework. The existing integration of Click with ns-2 (nsclick) has several limitations, namely it cannot be used with generic traffic generators, transport protocols and Net...

The phenomenon of paid search advertising has now become the most predominant form of online advertising in the marketing world. However, we have little understanding of the impact of search engine advertising on consumers‘ responses in the presence of organic listings of the same firms. In this paper, we model and estimate the inter-relationship between organic search listings and paid search ...

In this paper, we examine how different ranking and personalization mechanisms on product search engines influence consumer online search and purchase behavior. To investigate these effects, we combine archival data analysis with randomized field experiments. Our archival data analysis is based on a unique dataset containing approximately 1 million online sessions from Travelocity over a 3-mont...

Data are reported from a population of untrained individuals under lag- and single-click conditions in a discrimination suppression precedence-effect task. The cue to be discriminated was an interaural level-difference (ILD). Each of 91 observers completed 10 runs in a two-interval forced-choice design under a lag-click condition and three runs under a single-click condition. Stimuli were 125-m...

Click models are an important tool for leveraging user feedback, and are used by commercial search engines for surfacing relevant search results. However, existing click models are lacking in two aspects. First, they do not share information across search results when computing attractiveness. Second, they assume that users interact with the search results sequentially. Based on our analysis of...

A Click-based network function (NF) has significant advantages for pipeline development, including modularity, extensibility, and programmability. Despite these features, its internal architecture unfortunately not kept up with some specific problems of the software upgrade. To motivate our article, we analyzed a series use cases to identify limitations native Click. These include inefficiencie...

Emitted biosonar clicks and auditory evoked potential (AEP) responses triggered by the clicks were synchronously recorded during echolocation in an Atlantic bottlenose dolphin (Tursiops truncatus) trained to wear suction-cup EEG electrodes and to detect targets by echolocation. Three targets with target strengths of -34, -28, and -22 dB were used at distances of 2 to 6.5 m for each target. The ...