Orofacial cleft is one of the most significant birth defects across the globe. The focus of this work is to highlight the most recent advances in understanding of cleft lip and palate occurrence. Information regarding research on long time outcomes, genes, and their interactions with other genes are compiled to provide the overview on the current knowledge of the etiology of cleft lip and palat...

The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by oral gavage; ii) control group, mice were treated with an equal volume of corn oi...

BACKGROUND The chosen method of speech assessment, including type of speech material, may affect speech judgement in children with cleft palate. AIM To assess the effect of different speech materials on speech judgement in 5-year-old children born with or without cleft palate, as well as the reliability of materials by means of intra- and inter-transcriber agreement of consonant transcription...

Cleft lip and palate represent a major public health problem due to the possible associated life-long morbidity, complex etiology, and the extensive multidisciplinary commitment required for intervention. It affects about 1.5 per 1000 live births (250,000 new cases per year) worldwide, with tremendous variations across geographic areas and ethnic groups. It is considered a debilitating conditio...

UNLABELLED Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face, corresponding to approximately 65% of all malformations of the craniofacial region. AIM to describe unusual clinical cases of non-syndromic CL/P (CL/PNS), diagnosed in a reference service in Minas Gerais, Brazil, and correlate these alterations with possible risk factors. MATERIALS AND METH...

Significant heterogeneity has previously been reported but with no consensus on the prevalence of dental anomalies in subjects with a cleft lip and palate (CLP), thus, the purpose of this study was to investigate the frequency of various dental anomalies in the upper dental arch in different cleft groups. Diagnostic records, i.e., panoramic, occlusal and periapical films, dental casts, and intr...

OBJECTIVES/HYPOTHESIS To determine the prevalence of long-term hearing loss in patients with cleft palate who fail their universal newborn hearing screen. STUDY DESIGN The study is a retrospective chart review from a tertiary pediatric center and tertiary children's hospital. METHODS Newborns with cleft palate born between January 2002 and July 2012 were identified from a pediatric otolaryn...

Cleft palate and lips are the most common congenital anomalies affecting new born. It can occur isolated or together in various combination and/or along with other deformities. Most difficulty due to this type of newborn children’s while feeding, which because complete absence oral seal required during sucking milk. Early surgical intervention can’t be given such patient till age 6 months that ...

BACKGROUND A high incidence of orofacial clefts is reported in China, but no data has shown the relation between cleft types and the incidence of other defects so far. The aim of this study is to assess the incidence of congenital heart diseases and other organic defects associated with different types of orofacial clefts. METHODOLOGY AND PRINCIPAL FINDINGS All children with orofacial clefts,...

Cleft of lip and palate are the most common serial congenital anomalies to affect orofacial region. Its occurrence can be isolated or together in various combination and/or along with other deformities. In addition aesthetic disfigurement, a child cleft suffers functional morbidity such as restricted maxillofacial growth, speech anomalies, swallowing feeding difficulties, hearing loss recurrent...