Drug elimination is described in terms of clearance from a well-stirred compartment containing uniform drug distribution. The term clearance describes the process of drug elimination from the body or from a single organ without identifying the individual processes involved. Clearance may be defined as the volume of fluid cleared of drug from the body per unit of time. The units for clearance ar...

Abstract Stretch flangeability tests are performed on cold rolled AHSS automotive steel grades for crack sensitivity evaluation. The ISO16630 procedure is used with different cutting edge conditions including clearance, tool wear, angle and hole expansion punch geometry. Among all influence parameters, the clearance considered to be most critical control. Low (<10%) high (>20%) clearances...

Dopamine transporter (DAT) inhibitors are expected to decrease dopamine (DA) clearance from the extracellular space of the brain. However, mazindol and cocaine have been reported to "anomalously" increase DA clearance rate. To better understand in vivo DAT activity both in the absence and presence of DAT inhibitors, clearance of exogenously applied DA was measured in dorsal striata of urethane-...

The nonlinear thermo-mechanic coupling effect refers to the interaction between dynamic characteristics of a dual-rotor system and thermal an intershaft bearing. In this paper, is proposed studied by operating radial clearance load A model under bearing established considering factors such as Hertzian contact force obtained based on responses system. Based this, proposed. attained according tem...