PROSITE database contains a set of entries corresponding to protein families, which are used to identify the family of a protein from its sequence. Although patterns and profiles are developed to be very selective, each may have false positive or negative hits. Considering false positives as items that reduce the selectiveness of a pattern, then, the more selective pattern we have, a more accur...

aim: this study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.background: breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. there is some evidence that while the incident of breast cancer in young women is high, it is repo...

data regarding the effects of dietary protein on modifying serum lipid and lipoprotein levels are controversial. in this study we have investigated the hypothesis whether dietary protein and protein to carbohydrate ratio could be related to subsequent changes in lipid profile in adults.this 3-yaers follow-up_longitudinal study was conducted on a sample of participants (845 men and 1043 women, a...

objective too much restriction of dietary proteins can cause severe protein malnutrition,which can occur in adjusting the diet for some kinds of aminoacidopathies, urea cycle disorder and organic academia. this report presents the case of a 1.5-year-old boy with history of phenylketonuria with a three weeks history of erythematous scaly plaques and edema of his extremities; he had a history of ...

background: the incidence of ulcerative colitis (uc) is rising in populations with western-style diet, rich in fat and protein, and low in fruits and vegetables. in the present study, we aimed to evaluate the association between dietary protein intakes and the risk of developing incident uc.   methods : sixty two cases of uc and 124 controls were studied using country-specific food frequency qu...

Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...

aim : evaluation of biological characteristics of 13 identified proteins of patients with cirrhotic liver disease is the main aim of this research.   background : in clinical usage, liver biopsy remains the gold standard for diagnosis of hepatic fibrosis. evaluation and confirmation of liver fibrosis stages and severity of chronic diseases require a precise and noninvasive biomarkers. since the...

host innate immunity can affect the clinical outcomes of helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and malt lymphoma. nucleotide binding oligomerization domain (nod)-1 and -2 are two molecules of innate immunity which are involved in the host defense against h. pylori . this study aimed to evaluate the effect of the expression level of nod1 and n...

host innate immunity can affect the clinical outcomes of helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and malt lymphoma. nucleotide binding oligomerization domain (nod)-1 and -2 are two molecules of innate immunity which are involved in the host defense against h. pylori . this study aimed to evaluate the effect of the expression level of nod1 and n...

conclusions there is an as yet unexplained association between hcv and host parameters with unknown mechanisms in patients with chronic hcv infection. the assessments of core aa 70 substitution and polymorphisms near the ifnl3 gene could offer promising steps to improve the management of patients with hcv. background molecular studies have demonstrated that the hepatitis c virus (hcv) genotype ...