The CIR Expert Panel (Panel) assessed the safety of citric acid, 12 inorganic citrate salts, and 20 alkyl citrate esters as used in cosmetics, concluding that these ingredients are safe in the present practices of use and concentration. Citric acid is reported to function as a pH adjuster, chelating agent, or fragrance ingredient. Some of the salts are also reported to function as chelating age...

Male Wistar-strain rats which had been fed a glycolic-acid diet developed severe nephrocalcinosis with urinary calculi within 4 weeks. Rats fed the same diet with citrate salts added had, however, either slight or no nephrocalcinosis without any stones in the urinary system. Nephrocalcinosis intermediate between those in the citrate groups and the glycolic-acid group, with some urinary calculi,...

Abstract: The main aim of this study is to investigate about citric acid production by ETGP12 and ETGP18 strains of Aspergillus niger with the inclusion of certain nutrients along with the substrates. The substrates (rice chaff and sesamum oil cake) were fermented in the presence of different nutrients like ammonium carbonate and potassium dihydrogen phosphate at concentrations ranging from 0.1...

Cherimoya (Annona cherimola Mill.) is a subtropical fruit characterized by a significant increase in organic acid levels during ripening, making it an interesting model for studying the relationship between acidity and fruit flavor. In this work, we focused on understanding the balance between the concentration of organic acids and the gene expression and activity of enzymes involved in the syn...

The biodegradation of iron-citrate complexes depends on the structure of the complex formed between the metal and citric acid. Ferric iron formed a bidentate complex with citric acid, [Fe(III) (OH)(2) cit] involving two carboxylic acid groups, and was degraded at the rate of 86 muM h. In contrast, ferrous iron formed a tridentate complex with citric acid, [Fe(II) cit], involving two carboxylic ...

Abstract: Citric acid is a tri carboxylic organic acid is the most important acid produced by fermentation used in the food and pharmaceutical industries. The present work deals with the determination of optimum growth conditions for citric acid production by submerged fermentation by using strain of A.niger MTCC662 respectively. Isolation, screening and mutated the A.niger strain induced by UV...

quiet, single room for the 24-h test period; studies were done at 1:00 PM and 1:00 AM, both in supine position with a closefitting face mask and nasal packing to ensure mouth breathing. Subjects inhaled nebulized saline solution (control) and citric acid, delivered by an ultrasonic nebulizer. The citric acid was dissolved in the saline solution, providing incremental concentra¬ tions from 0.3 t...

The reversal of the mitochondrial isocitrate dehydrogenase reaction was investigated in rat livers perfused with [U-13C5]glutamate or [U-13C5]glutamine. The mass isotopomer distribution of citric acid cycle intermediates extracted from the livers was determined by gas chromatography-mass spectrometry. Citrate was enriched in an isotopomer containing five 13C. The formation of this isotopomer ca...

bioremediation of heavy metals remains a major challenge in environmental biotechnology. biosorption is a novel technique for decreasing metal ion content in the waste water. biosorption experiments for cu (ii) were investigated in this study using bacteria isolated from the industrial effluent. the results showed that the dead cells of pseudomonas sp. were an efficient adsorbent of cu (ii). fo...

in this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. the condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. the advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.