Acitretin, a beneficial retinoid, was shown to undergo constant structural interconversions among its geometrical isomers (all-trans-acitretin, 9-cis-acitretin, 13-cis-acitretin, 9, 13-di-cis-acitretin, etc.) by photoisomerization under natural light. The photoisomerization was zero order reaction with an apparent velocity of 4x107 M/min under illumination by white fluorescent lamps (1, 200 lx)...

EGFR-tyrosine kinase inhibitors (TKIs) have revolutionized the treatment for NSCLC. However, acquired drug resistance often occurs after with EGFR-TKIs. EGFR T790M and C797S mutations are most common mechanism in patients who failed from first- third- generation TKI treatments, respectively. there is no standard of care NSCLC harboring in-cis. The present case reports a 69-year-old Chinese man ...

cis-4-Propylcyclohexanol is an important intermediate for synthesizing trans-2-(4-propylcyclohexyl)-1,3-propanediol, which widely used in the manufacture of liquid crystal displays. In this study, cis-4-propylcyclohexanol was prepared using a mutant alcohol dehydrogenase from Lactobacillus kefir (LK-TADH, A94T/F147L/L199H/A202L) coupled with glucose dehydrogenase. Using optimal catalytic condit...

Objective: This study aims to investigate and compare the anticancer effects of carboplatin cisplatin, frequently used in cancer treatment, by loading them on albumin nanocarrier. Materials Methods: Carboplatin (CP) Cisplatin (Cis) loaded nanoparticles were synthesized using ultrasonication as CP-NPs Cis-NPs, respectively. Nanoparticle size distribution evaluated Dynamic light scattering (DLS)....