Recently improved methods for visualization of thin tissue sections by electron microscopy have been applied to the study of early changes in the bronchial epithelium of mice infected by inhalation of aerosols of influenza virus. In confirmation of previous findings by the authors, inclusion bodies have been demonstrated in ciliated and non-ciliated cells of infected bronchial epithelium. In ad...

Human airway epithelium, the defence at the forefront of protecting the respiratory tract, evacuates inhaled particles by a permanent beating of epithelial cell cilia. When deficient, this organelle causes primary ciliary dyskinesia, and, despite numerous studies, data regarding ciliated cell gene expression remain incomplete. The aim of the present study was to identify genes specifically expr...

Mucociliary clearance is essential to the defense mechanisms of the respiratory system. Loss of normal mucociliary clearance contributes to the pathogenesis of genetic and acquired lung diseases. Treatment of cultured differentiated human airway epithelial tissue with IL-13 resulted in a loss of ciliated epithelial cells and an increase in mucus-secreting cells. The loss of ciliated cells was c...

Airway basal cells (BC) function as stem/progenitor cells capable of differentiating into the luminal ciliated and secretory cells to replenish the airway epithelium during physiological turnover and repair. The objective of this study was to define the role of Notch signaling in regulating human airway BC differentiation into a pseudostratified mucociliated epithelium. Notch inhibition with γ-...

Single palatal processes or homotypic paired palatal processes from 12-day mouse embryos (strain C57Bl) were grown in organ culture on Millipore filters. The epithelium along the medial edge of each palatal process became disrupted, and, by 72 hours of culture, paired palatal processes achieved mesenchymal fusion at the site of disruption. The nasal epithelium of paired palatal processes became...

症例は47歳，女性．5日前から心窩部痛が出現したため，当院へ来院．同部に圧痛を認めたが発熱なく，血液検査でもCRP軽度上昇以外は異常なかった．画像検査で肝円索部に厚い被膜を有する45mm大の嚢胞あり．感染性嚢胞を疑い抗菌薬を投与したところ，腹痛は数日で消失した．肝円索膿瘍の術前診断で手術を施行したところ，肝円索に5cm大の腫瘤が認められ，約1.5cmにわたって肝表面に接していた．摘出標本は55×33mm大の単房性嚢胞で，内腔には乳白色調の液体が貯留しており，病理組織学的に肝円索との連続性はなかった．嚢胞壁の内面は線毛を有する多列円柱上皮で被覆され，上皮下は疎性結合織，平滑筋層を有する線維性結合織からなり，線毛性前腸性肝嚢胞と診断された．自験例は，その発育が通常例のように肝被膜直下つまり内方向ではなく，肝円索への外方向であったため，肝円索膿瘍との鑑別に苦慮した1例であった．