The mechanism of apolipoprotein (apo) CIII-induced hypertriglyceridemia remains uncertain. We crossed apoCIII transgenic and apoE gene knockout (apoE0) mice, and observed severe hypertriglyceridemia with plasma triglyceride levels of 4,521+/-6, 394 mg/dl vs. 423+/-106 mg/dl in apoE0 mice, P < 0.00001 for log(triglycerides [TG]). Cholesterols were 1,181+/-487 mg/dl vs. 658+/-151 mg/dl, P < 0.000...

Az elmúlt években született nagy klinikai vizsgálatok csak erősítették és nem cáfolták, hogy annál jobb minél erélyesebben korábban kezdjük az aterogén koleszterin csökkentését. Ennek ellenére a 2021-es ESC prevenciós irányelv jelentősen visszaveszi 2019-es ESC/EAS-ajánlás progresszívitását. A HDL protektív hipotézisét viszont inkább cáfolták friss érdemi halolajjal nyert eredmények is ellentmo...

Bacillus subtilis RecN appears to be an early detector of breaks in double-stranded DNA. In vivo, RecN forms discrete nucleoid-associated structures and in vitro exhibits Mg2+-dependent single-stranded (ss) DNA binding and ssDNA-dependent ATPase activities. In the presence of ATP or ADP, RecN assembles to form large networks with ssDNA molecules (designated complexes CII and CIII) that involve ...

Farkhad G. Aliev,1,* Juan F. Sierra,1 Ahmad A. Awad,1 Gleb N. Kakazei,2,† Dong-Soo Han,3 Sang-Koog Kim,3 Vitali Metlushko,4 Bojan Ilic,5 and Konstantin Y. Guslienko3,6 1Departamento de Fisica de la Materia Condensada, CIII, Instituto “Nicolas Cabrera” de Ciencia de Materiales, Universidad Autonoma de Madrid, 28049 Madrid, Spain 2Departamento de Física da Faculdade de Ciências, IFIMUP and IN-Ins...

We have developed a technique, using a combination of immunofluorescence staining of semi-ultrathin sections of epoxy resin-embedded samples and the corresponding differential interference contrast (DIC) images and images in transmission mode obtained by confocal laser-scanning microscopy (LSM), that provides detailed information about the immunolocalization of antigens and histological and cel...

The circuitry of the phage λ genetic switch determining the outcome of lytic or lysogenic growth is well-integrated and complex, raising the question as to how it evolved. It is plausible that it arose from a simpler ancestral switch with fewer components that underwent various additions and refinements, as it adapted to vast numbers of different hosts and conditions. We have recently identifie...

Congenital generalized lipodystrophy is a rare inherited disease. One of its features is a disturbance in lipid metabolism characterized by hypercholesterolemia and hypertriglyceridemia. A brother and a sister with congenital generalized lipodystrophy, an 8-year old male and a 12-year old female were studied. The mother and a 6-year old brother were healthy. The genetic analysis of Sstl RFLP of...