نتایج جستجو برای: chronic systemic hypertension
تعداد نتایج: 777519 فیلتر نتایج به سال:
Systemic connective tissue diseases (CTDs) comprise a large group of that are auto-immune in nature and characterized by the involvement multiple systems organs. Pul-monary hypertension (PH) various etiologies may develop course CTD, including pulmonary arterial (PAH), PH secondary to lung disease, postcapillary left heart chronic thromboembolic (CTEPH). In addition, different forms coexist wit...
OBJECTIVE It has been reported that dehydroepiandrosterone is a pulmonary vasodilator and inhibits chronic hypoxia-induced pulmonary hypertension. Additionally, dehydroepiandrosterone has been shown to improve systemic vascular endothelial function. Thus, we hypothesized that chronic treatment with dehydroepiandrosterone would attenuate hypoxic pulmonary hypertension by enhancing pulmonary arte...
Hypertension defined as a systolic blood pressure of ≥140 and a diastolic blood pressure ≥90 is an extremely prevalent condition; and it is responsible for significant mortality and morbidity. NHANES data from 2005-2006 found that nearly 30% of adult US population has HTN; and nearly 8% of the population has undiagnosed HTN. HBP mortality in 2008 was 61,005. Any mentioned mortality in 2008 was ...
BACKGROUND AND OBJECTIVES Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein exp...
Mitochondria are essential for the onset of hypoxia-induced pulmonary vasoconstriction and pulmonary vascular-remodeling, two major aspects underlying the development of pulmonary hypertension, an incurable disease. However, hypoxia induces relaxation of systemic arteries such as femoral arteries and mitochondrial heterogeneity controls the distinct responses of pulmonary versus femoral artery ...
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