introduction worldwide, chronic liver disease is a major cause of morbidity and mortality. causes of elevated serum alanine aminotransferase (alt) levels vary depending on the population under study. the aim of this study is to evaluate the frequency and causes of persistently elevated alt levels in patients of the gastroenterology (gi) clinics in ghaem and emam reza hospitals in mashhad, iran....

A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The ac...

Human systemic lupus erythematosus (SLE) and its murine model, MRL lpr/lpr mice, are well known to develop a wide range of symptoms, such as glomerulonephritis, dermatitis, and arthritis, as an immune-complex disease. However, the deposition of circulating immune complex does not fully explain the tissue specificity of disease. Tissue-specific autoantigens may also be involved in tissue inflamm...

Atopic dermatitis (AD) is a chronic immune-mediated disease characterized by intense pruritis, causing inflammation, itching, and redness of the skin. Dupilumab human monoclonal antibody that has been approved for treatment atopic dermatitis. It also linked with various adverse effects, most them confined to injection site. Café-au-lait-macules are benign pigmented lesions skin, usually seen in...

One of the effects that occur in chronic kidney failure can cause metabolic waste not to be eliminated by kidneys and accumulate on skin, which causes itching or commonly known as pruritus. Treatments reduce pruritus use emollient oil baby keep skin moist. This implementation aims determine effectiveness disease (CKD) patients with uremic is based results previous research using experimental, p...

Chronic urticaria (CU) is a debilitating skin disease affecting around 1% of the population. CU can be subdivided into chronic spontaneous (CSU) and inducible (CIndU). Different pathophysiological mechanisms have been proposed to play role in development CU, these are also being investigated as potential biomarkers diagnosis management disease. As now only assessment tools available for treatme...

Rosacea is a multifactorial dermatological disease that widespread throughout the world, initially manifested as cosmetic defect, and in absence of systemic topical therapy leads to change structure functions facial skin.
 Patients with rosacea often seek medical attention, these aesthetic problems impair their quality life contribute development social psychological problems. Chronic stre...

Anti-tumor necrosis factor (anti-TNF) agents have been successfully used to treat both chronic idiopathic inflammatory bowel disease and other immune-mediated chronic diseases, but they can also induce a wide array of cutaneous reactions, including new-onset psoriasis and alopecia. We report a case of alopecia associated with psoriasiform skin lesions in a patient on adalimumab treatment for Cr...