Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of prolifera...

Background & Aim: The most therapeutic properties of different species of Pinus class are antimicrobial and anti-inflammatory characteristics, soothing effect, resolver of skin itches, wound, acne and rash healer and improvement of ulcers and chronic lesions. In ancient medical literature of Iran, different parts of Pinus classes, particularly its resin, had been used for treat...

Wound healing is a complex regulated process that results in skin scar formation in postnatal mammals. Chronic wounds are major medical problems that can confer devastating consequences. Currently, there are no treatments to prevent scarring. In the early fetus wounds heal without scarring and the healing process is characterized by relatively less inflammation compared to adults; therefore, re...

Wounds are common in oral cavity, caused by either trauma or surgery. Soft tissue wound healing in oral cavity proceeds along the same principles as in other areas of the body such as the skin. Wound healing always starts with the blood clotting that initially seals the wound (Chapter 2). Platelet activation during the primary hemostasis releases a number of important cytokines that start the h...

1 Sydney Medical School, University of Sydney, Sydney, 2006 NSW, Australia 2 Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia Foot ulceration, secondary to diabetes, is the most common reason for lower limb amputation, accounting for 50-70% of non-traumatic lower limb amputations. Rather than progressing through the usual wound healing phases, diabet...

Wound healing is an intricate process that involves many types of cells, reaction pathways as well as chemical, physical and electrical cues. Since biochemical reactions and physiological events are pH-dependent we study here pH as an important major characteristic of the wound healing process in the presence of endogenous and exogenous electric fields. Our model gives the spatial pH distributi...

BACKGROUND Refractory surface of wound and dermal chronic ulcer are largely attributed to poor neovascularization. We have previously shown that E2F1 suppresses VEGF expression in the ischemic heart, and that genetic deletion of E2F1 leads to better cardiac recovery. However, whether E2F1 has a role in dermal wound healing is currently not known. METHODS AND RESULTS Skin wounds were surgicall...

Background and aim: Improvement of wound healing in normal subjects and in chronic ulcers has been always desired. The availablity and acceptability of herbal medicine led us to study the effect of topical 10% mucilage of quince seed in human skin.Materials and Methods: This double-blind clinical trial has been conducted on 34 patients referring to Imam Hospital, clinic...

Background Pain is one of the key characteristics which distress patients with chronic wounds. Chronic wound pain has a significant impact on the patient’s quality of life and delays wound healing. Assessment and management of pain during wound dressing changes is well addressed, however, chronic persistent wound pain is underassessed and under-treated resulting in patients’ perception that wou...