BACKGROUND A biologically plausible link between gastro-oesophageal reflux (GOR), aspiration, and lung allograft dysfunction has been suggested, but there is no systematic evidence indicating the presence of gastric contents in the lung. We have tested the hypothesis that pepsin, as a marker of aspiration, is detectable in bronchoalveolar lavage (BAL) fluid of allograft recipients who had not r...

BACKGROUND We summarize our experience in the pathological diagnosis of late complications of liver transplantation (LT) to better understand the causes of late allograft dysfunction in a population mostly composed of patients with hepatitis B virus (HBV) infection. METHODS We reviewed 361 post-transplant liver biopsies from 174 patients who underwent LT and first presented with liver functio...

background: imatinib mesylate is the first generation of tyrosine kinase inhibitors (tki) and highly effective in the treatment of chronic myeloid leukemia (cml). we aimed to evaluate thyroid function at baseline and at 1, 3, 6 and 12 months after initiation of imatinib mesylate therapy in 20 newly diagnosed bcr-abl positive cml patients. methods: this study was done during 2013-2014, 20 new ca...

background: calcineurin inhibitors (cni) have significantly reduced the incidence of acute rejection. nephrotoxicity however may contribute to long-term allograft dysfunction. mycophenolate mofetil (mmf) may allow cyclosporine (csa) dose reduction without increasing the risk of rejection. methods: in seventy-eight living unrelated kidney transplant patients with renal dysfunction, we studied th...

UNLABELLED HLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expr...

A healthy endothelium is essential for vascular homeostasis, and preservation of endothelial cell function is critical for maintaining transplant allograft function. Damage to the microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection, an important predictor of graft loss. It is also linked with transplant vasculopathy, often associated with chro...

Abstract Pulmonary arterial hypertension (PAH) is a rare and severe disease characterised by the progressive narrowing of small pulmonary arteries resulting in right-sided heart failure. Despite advances treatment, some PAH patients require lung transplantation, which carries risks long-term complications. We report case male patient with no significant comorbidities, who developed dyspnoea on ...