INTRoDucTioN................................................................ 320 EXPERIMENTAL APPROACH...................................................... 321 MATERIALS AND METHODS..................................................... 321 Media................................................................... 321 Bacterial Strains............................................................ 32...

Premature Ovarian Failure (POF) defined as functional stop of ovaries before the age of 40. It is a common cause of infertility in women that characterized by primary or secondary amenorrhea, high gonadotropin levels and estrogen level declining in patients. Factors that reduce follicle or defect in the follicle growth stimulating mechanism defined as numerous complication factors that they can...

Human telomeres play a major role in stabilizing chromosome ends and preventing fusions. Chromosomes bearing a broken end are rescued by the acquisition of a new telomeric cap without any subtelomeric sequences being present at the breakpoint, a process referred to as chromosome healing. Conversely, a loss of telomeric function or integrity can lead to the presence of interstitial telomeres at ...

The albino deletion complex in the mouse represents 37 overlapping chromosomal deficiencies that have been arranged into at least twelve complementation groups. Many of the deletions cover regions of chromosome 7 that contain genes necessary for early embryonic development. The work reported here concentrates on two of these deletions (c6H, c11DSD), both of which were known to be lethal around ...

Introduction . 13q14 deletion is the most common chromosomal abnormality in chronic lymphocytic leukemia (CLL), and as sole determines favorable prognosis of disease. Using molecular genetic methods two subtypes were identifi ed based on size lost material: small (type I) with involvement D13S319 segment containing MIR15A / MIR16-1 DLEU1 genes large II) centromeric region involving RB1 gene. Da...

Two general types of clonal chromosome abnormality are observed in de novo acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of chromosome material and the balanced aberrations without such visible gain or loss. AML can be induced by therapy with cytostatic drugs and radiation. The alkylating agents reacting directly with DNA induce AML which often presents as m...