نتایج جستجو برای: chromosomal translocation
تعداد نتایج: 87647 فیلتر نتایج به سال:
Activation of proto-oncogenes and inactivation of tumor suppressor genes (TSGs) occur during multistage carcinogenesis. Proto-oncogenes are activated by gene amplification, point mutation and chromosomal translocation, while TSGs are inactivated by promoter CpG hypermethylation, point mutation, chromosomal translocation, and deletion. Array CGH combined with mRNA microarray analysis is applied ...
Early relapse and minimal residual disease during clinical remission was examined in two patients having acute T-cell leukemia/lymphoma with the t(10;14)(q24;q11) chromosomal translocation. Molecular probes which can detect T-cell receptor alpha/delta clonal rearrangements and a TCL-3 probe which can detect the clonal rearrangement due to the chromosomal translocation failed to detect the leuke...
Although rare, mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland tumors. The presence of the t(11;19)(q21;p13) translocation in a subset of MECs has raised interest in genomic aberrations in MEC. In the present study we conducted genome-wide copy-number-aberration analysis by micro-array comparative-genomic-hybridization on 27 MEC samples.Low/intermediate-grade M...
objective: to verify the hypothesis that the incidence of chromosomal abnormalities increases in babies conceived by different assisted reproduction procedures. the availability of the umbilical cord blood encouraged us to study this hypothesis via this method. materials and methods: this is a descriptive study, umbilical cord blood samples of assisted reproductive technology (art) children wer...
Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their genesis is limited. To examine the origins of chromosomal rearrangements we devel...
Chromosomal translocations have proven to be important markers of the genetic abnormalities central to the pathogenesis of cancer. By cloning chromosomal breakpoints one can identify activated proto-oncogenes. We have studied a case of B-lineage acute lymphocytic leukemia (ALL) that was associated with peripheral blood eosinophilia. The chromosomal translocation t(5;14) (q31;q32) from this samp...
Reciprocal translocations (RecT) and Robertsonian translocations (RobT) are among the most common chromosomal abnormalities that cause infertility and birth defects. Preimplantation genetic testing for aneuploidy using comprehensive chromosome screening for in vitro fertilization enables embryo selection with balanced chromosomal ploidy; however, it is normally unable to determine whether an em...
Chromosomal translocations are implicated as important pathogenetic events in many human malignancies (1) . For tumors of B-lymphoid origin, the Ig genes are frequent sites of chromosomal translocations, most commonly resulting in juxtaposition of Ig genes with the c-myc or bcl-2 genes (2) . In rare T cell cancers, the TCR-a gene may be translocated into close proximity of the c-myc protooncoge...
Chromosomal translocations are frequently associated with a wide variety of cancers, particularly hematologic malignancies. A recurrent chromosomal abnormality in acute myeloid leukemia is the reciprocal translocation t(8;21) that fuses RUNX1 and ETO genes. We report here that Wnt/β-catenin signaling increases the expression of ETO and RUNX1 genes in human hematopoietic progenitors. We found th...
BACKGROUND Acute promyelocytic leukemia is characterized by a typical reciprocal translocation t(15;17)(q22;q21). Additional chromosomal abnormalities are reported in only 23-43 % of cases of acute promyelocytic leukemia. CASE PRESENTATION Here we report the case of a 46-year-old Syrian Alawis woman with acute promyelocytic leukemia with the typical t(15;17) translocation, but with a second c...
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