Mouse spermatozoa and androgenetic one-cell embryos (androgenones) at various developmental stages were exposed to etoposide (1 μM), a topoisomerase II (topo II) poison, or to either of two catalytic inhibitors: ICRF-193 (10 μM) or merbarone (50 μM), for 2 h in order to study the clastogenic effects of these drugs on remodeled sperm chromatin. None of the drugs induced structural chromosome abe...
