PURPOSE To correlate fundus autofluorescence (FAF) patterns in choroidal melanocytic lesions with changes present on the surface of such lesions, including lipofuscin, hyperpigmentation, drusen, and fibrous metaplasia, and to describe the effect of treatment on FAF. METHODS Retrospective chart review of 23 consecutive patients with choroidal nevi and melanoma who underwent FAF photography. Th...

OBJECTIVE To evaluate choroidal halo nevus. METHODS We performed a retrospective medical record review on all patients with a clinical diagnosis of choroidal halo nevus treated at the Ocular Oncology Service at Wills Eye Institute from April 1, 1974, through June 30, 2008. Their clinical characteristics and natural history were studied. RESULTS The choroidal halo nevus showed 2 components, ...

BACKGROUND/AIMS The purpose of this study was to examine the clinical presentations and pathological features of spontaneously necrotic choroidal melanomas. METHODS The clinical and histological features of patients who underwent enucleation for uveal melanoma from 1989 to 2012 at Emory University and were found to have spontaneously necrotic choroidal melanomas were retrospectively analyzed....

PURPOSE To investigate the presence of known cytogenetic alterations of choroidal melanoma in a series of patients diagnosed and treated in our Ocular Oncology Service. A review of the present literature on this topic is also presented. METHODS Microsatellite analysis (MSA) studies on loss of heterozygosity (LOH) of chromosome 3, as well as multiplex ligation prove amplification (MLPA) on chr...

Intraocular tumors are rare in the dog. Of the reported neoplasms, melanomas are the most common. These tumors characteristically arise in the anterior uvea and secondarily infiltrate posteriorly into the choroid and/ or anteriorly into the corneoscleral region. Advanced tumors may extend extraocularly. In the dog, isolated choroidal melanomas are extremely uncommon; to the authors' knowledge, ...

PURPOSE The purpose of this study was to correlate high-resolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. METHODS With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologi...

BACKGROUND Intraschisis hemorrhage of dark green color without accompanying vitreous hemorrhage is a rare complication of degenerative retinoschisis-detachment. CASE A 37-year-old male patient with unilateral intraschisis hemorrhage closely mimicking a choroidal melanoma is described. OBSERVATIONS Ultrasonography and intravenous fluorescein angiography suggested intraschisis hemorrhage. T(1...

PURPOSE To determine whether iodine 125 brachytherapy or enucleation is better for quality of life in patients treated for choroidal melanoma. PATIENTS AND METHODS Sixty-five patients with choroidal melanoma were treated with a modified version of VF-14 iodine 125 brachytherapy, enucleation or both. Results of this treatment were then statistically analyzed. RESULTS Statistically significan...

The diagnosis of small choroidal melanomas may be difficult, and the natural history of these small tumours is poorly understood. We followed up 20 patients with the diagnosis of small choroidal melanomas for from 2 to 20 years. In 11 of these patients the melanoma was observed to grow. Nine of these patients have undergone enucleation. Eight of the eyes contained spindle B melanomas and one co...

We evaluated 55 samples of choroidal melanoma managed by enucleation. Knowing that the immunohistochemical expression of the retinoblastoma gene family members Rb/p105, p107, and pRb2/p130 was inversely correlated with the degree of malignancy in at least some histological types, we investigated the expression of these three proteins in choroidal melanoma. We focused on the relationship between...