The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1-weighted MRI scans were performed on the right knee to assess bone marrow lesions at lateral tibia and femora and medial tibia and femora, as well as chondral defects. A radiograph was taken on the same knee and scored for indi...

The therapeutic value of microfracture has been demonstrated in clinical patients. The rationale is that focal penetration of the dense subchondral plate exposes cartilage defects to the benefits of cellular and growth factor influx in addition to improving anchorage of the new tissue to the underlying subchondral bone and, to some extent, the surrounding cartilage. While functional outcomes ha...

INTRODUCTION: Post -traumatic arthritis is one of the most common causes of secondary osteoarthritis (OA). While the mechanisms leading to a posttraumatic OA are currently not well understood, in acute experiments severe traumatic insults to chondral and osteochondral explants have documented both extensive cartilage matrix damage and chondrocyte death. These in vitro tissue damages closely res...

Osteoarthritis (OA) is the most important rheumatic disease aff ecting mankind. Where risk factors have been identifi ed, such as in knee and hip OA, with few exceptions, no prevention strategies are well substan tiated enough or have proven benefi t to justify wide spread dissemination. Th e major risk factors for knee OA are advanced age, injury and obesity [1]. However, there is limited or n...

OBJECTIVE The purpose of our study was to determine the effectiveness of cartilage repair utilizing 1-step surgery with bone marrow aspirate concentrate (BMAC) and a collagen I/III matrix (Chondro-Gide, Geistlich, Wolhusen, Switzerland). MATERIALS AND METHODS We prospectively followed up for 2 years 15 patients (mean age, 48 years) who were operated for grade IV cartilage lesions of the knee....

The purpose of this study was to evaluate long-term outcome, following microfracture of the knee in a large patient group, using a random-effect model for longitudinal data analysis. There were 350 subjects (males, 55%; females, 65%) who underwent knee microfracture by a single surgeon between 1992 and 2002. Mean age was 48 years (range, 12-76 years). Subjective questionnaires were collected fr...

BACKGROUND AND PURPOSE The natural history of, and predictive factors for outcome of cartilage restoration in chondral defects are poorly understood. We investigated the natural history of cartilage filling subchondral bone changes, comparing defects at two locations in the rabbit knee. ANIMALS AND METHODS In New Zealand rabbits aged 22 weeks, a 4-mm pure chondral defect (ICRS grade 3b) was c...

OBJECTIVE To assess the reproducibility of the Outerbridge and the French Society of Arthroscopy classifications between different observers, and to establish a comparison between them. METHOD Thirty videos on randomly selected knee arthroscopy procedures demonstrating chondral lesions were used. These were classified by six observers: two third-year orthopedics residents and four orthopedic ...

BACKGROUND The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of...