Arsenic is an environmental toxicant, and one of the major mechanisms by which it exerts its toxic effect is through an impairment of cellular respiration by inhibition of various mitochondrial enzymes, and the uncoupling of oxidative phosphorylation. Most toxicity of arsenic results from its ability to interact with sulfhydryl groups of proteins and enzymes, and to substitute phosphorus in a v...

biomarkers are assigned as early warning systems regarding aquatic organisms exposed to pollutants. among which, however, measurement of esterase enzymes activity specially cholinesterase of fish tissues, is a marker for exposure to organophosphate pesticide and carbamates, and this biomarker has been used widely in broad range of investigations. a number of capoeta capoeta gracilis (:cyprinida...

In 1986, Whittaker wrote ‘Churchill-Davidson’s editorial entitled “The succinylcholine story” in 1963, highlighted probably for the first time in the UK, the role of serum protein polymorphism in drug sensitivity’ [1]. Following a series of detailed family studies, in 1959 Kalow [2] concluded that individuals who had prolonged apnoea following succinylcholine administration were homozygous for ...

Organophosphate chronic toxicity has been evaluated in this study. Biological screening for organophosphate insecticide-exposed workers is mostly recommended for mixers, loaders, formulators and spraymen. We have studied 17 occupationally exposed persons to pesticides. Using Ellman's colorimetric method, their plasma cholinesterase activities have been measured. Results show that the appear...

The most prevalent illnesses that affect the liver are viral infections; when cell is destroyed by viruses, it loses its function and of body's processes compromised. primary source serum cholinesterase. Therefore, cholinesterase can be used as a predictive biomarker for liver's synthetic capability. This study aims to evaluate in patients with hepatitis B virus (HBV) or C (HCV). was conducted ...

Background: Chronic liver disease in the clinical context is a process of that involves progressive destruction and regeneration parenchyma leading to fibrosis cirrhosis1. The serum cholinesterase mainly synthesized it released into blood, which reduced dysfunction due synthesis, marked reduction restoration synthesis with hepatocyte recovery suggest activity might be more specific marker than ...