Introduction Hypercholesterolemia is one of the major established risk factors for coronary heart disease (CHD), with CHD being one of the five leading causes of death in the Asia–Pacific countries.1 Hypercholesterolemia is affected by genetic, diet, disease state and environmental factors. Recently, attention has been focused on the nutritional programming in perinatal period and the diseases ...

These findings have implications for the strategies used to encourage general practitioners to base their practice on clinical evidence. Teaching general practitioners critical appraisal skills and developing guidelines may redress identified skill deficiencies and distil trial data in accessible form, but universal awareness and acceptance of trial findings alone may not lead to their integrat...

United States is in the midst of an epidemic of obesity. Children and adults alike are increasing in girth at rapid rates. In the past four decades, the prevalence of childhood overweight, characterized by a body mass index greater than the norm for the 85th percentile, has risen by nearly 4-fold and continues to rise with each year (Ogden et al. 2002). Fifteen percent of children today are ove...

cholesterolemia and osteoarthritis was treated with atorvastatin 10 mg daily for four months, ending in October 2006. At that time, hypothyroidism was diagnosed, and the atorva statin was temporarily discontinued. She returned to our lipid clinic in September 2009, because her total and low-density-lipoprotein [LDL] cholesterol levels were signi ficantly increased. At this point, rosuva statin ...

Plasma lipoprotein changes were monitored for 12 hr after a fat-rich meal (1 g of fat/kg body weight) in 22 subjects (9 males, 13 females, 22-79 yr old). Plasma triglyceride, measured hourly, peaked once in some subjects, but twice or three times in others. The magnitude of postprandial triglyceridemia varied considerably between subjects (range: 650-4082 mg.hr/dl). Males tended to have greater...

We read the article ''Prevalence of hypertension in Por-tuguese adolescents in Lisbon, Portugal'' by Silva et al. 1 with interest. They investigated the prevalence of pre-hypertension and hypertension (HT) in Portuguese adolescents in Lisbon to ascertain the relationship between blood pressure (BP) levels and the risk factors of gender, obesity , smoking, alcohol consumption, exercise and famil...

UNLABELLED BACKGROUND PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a circulating protein that promotes hypercholesterolemia by decreasing hepatic LDL receptor protein. Under non interventional conditions, its expression is driven by sterol response element binding protein 2 (SREBP2) and follows a diurnal rhythm synchronous with cholesterol synthesis. Plasma PCSK9 is associated to...

A 62-year-old retired account executive complains of diffuse chest pain with moderate activity. His hyper-cholesterolemia and hypertension have been well controlled. On treadmill testing , he fatigues at a heart rate of 140 bpm. You discuss the option of a pharmacological stress radionuclide study, but his reaction is concern. When questioned , he divulges that he and his wife had recently read...