Chlorpromazine is a phenothiazine antipsychotic which is often used in hospice and palliative care to treat hiccups, delirium, and nausea. With the discontinuation of the commercial oral solution concentrate, there is a need to prepare this product by extemporaneous compounding. This study was initiated to identify an easy-to-prepare formulation for the compounding pharmacist. A stability study...

Numerous reports including Courvoisier et al. (1) have been made of the pharmacolo gical studies on chlorpromazine. The action of chlorpromazine on the central nervous system has been studied in reference to electroencephalography and evoked potentials from the brain of animal. Although the action mechanism of the drug has been well explained, much seems still left unclarified. The most conspic...

The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic effects or complications due to chlorpromazine, but most of these studies explor...

Liver ischemia in intact rats is associated with a series of alterations in mitochondrial structure and function that include: a complete loss of respiratory control; a loss of adenine nucleotide translocase activity; decreases in, at least, the heme portions of cytochromes aa and c + cl; a decrease in dinitrophenolactivated ATPase; a loss of the ability of dinitrophenol to stimulate 02 uptake;...

1. Phosphatidate phosphohydrolase from the particle-free supernatant of rat liver was assayed by using emulsions of phosphatidate as substrate. 2. The inhibition of the phosphohydrolase by chlorpromazine was of a competitive type with respect to phosphatidate. The potency of various amphiphilic cationic drugs as inhibitors of this reaction was related to their partition coefficients into a phos...

Combination therapy has proven successful in treating a wide variety of aggressive human cancers. Historically, combination treatments have been discovered through serendipity or lengthy trials using known anticancer agents with similar indications. We have used combination high-throughput screening to discover the unexpected synergistic combination of an antiparasitic agent, pentamidine, and a...

The influence of single and repeated doses of morphine, pentazocine, and chlorpromazine on the latent time of cortical evoked potentials was observed in rats. The evoked potentials were induced by electrical stimulation of the sciatic nerve under the condition of curarization and artificial respiration. The evoked potential consisted of 4 phases. The latent time of the N2 component was prolonge...

Chronic ingestion of large doses of chlorpromazine (CPZ) by human beings has been associated with the production of corneal and lens opacities, and less frequently with chorioretinal pigmentation, and a peculiar purplish coloration of exposed skin and conjunctiva. When guinea pigs were fed large doses of CPZ and exposed to ultraviolet light, lens opacities were consistently produced that resemb...

as Halifax in the north and Rotherham in the south. I do not think that my colleagues should accept his advice uncritically. I do not feel that I could recommend to hospital authorities in this area that they should accommodate and supervise large numbers of such patients in an area where skilled profess-onal manpower is hard to come by. I believe that this problem should be tackled in co-opera...