The influence of half-life on the postantibiotic effect (PAE) of tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus was investigated during one dosing interval. Tobramycin half-lives of 0.5 to 2.5 h were simulated in an in vitro model, and the PAE was determined by an enzymatic inactivation method at different time points, i.e., when the tobramycin concentrations were 20x, 5x, ...

The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of tigecycline were determined for 14 gram-positive and gram-negative organisms. The pneumococcal, staphylococcal, and enterococcal PAEs were 1.9 to 5.1, 2.9 to 5.7, and 3.9 to 6.1 h, respectively, and those for Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, Enterobacter c...

The following information is missing from the Funding section: This study was supported by UEMOA (P-Z1 – IAD – 002 PAES project number 2100155007376). Copyright: © 2016 Ehounoud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a...

Incubation of crude enzyme preparations from leukemia L1210 ascites cells with l,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) caused decreases in the DNA nucleotidyltransferase activity. l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea was as active as BCNU, but l-(2-chloroethyl)-l-nitrosourea and 1methyl-1-nitrosourea were much less active. 2-Chloroethyl isocyanate was about equal to BCNU in activity...

The compound 2-chloroethyl isocyanate, a decomposi tion product of 1,3-bis(2-chloroethyl)-1-nitrosourea, was studied for its effects on excision repair of DNA in normal human fibroblasts exposed to ultraviolet (UV) radiation. For examination of the initial step in repair (UV endonuclease), the frequency of UV-induced strand breaks was analyzed by alkaline elution. Repair polymerase activity was...

The effects of 1,3-bis(2-chloroethyl)-1-nitrosourea on the rejoining of X-ray-induced DNA strand breaks were examined in normal human fibroblasts (WI-38) and a simian virus 40-transformed derivative (VA-13) with the use of alkaline sucrose sedimentation. 1,3-Bis(2-chloroethyl)-1nitrosourea was capable of partially inhibiting repair of Xray-produced DNA strand breaks in both cell types when the ...

N,N-dichloropolystyrene sulfonamide as a decontaminant was synthesized in 5 steps from styrene monomer. Styrene was first polymerized. Then, sulfonation reaction was performed by H2SO4 (c) followed by chlorination with POCl3 obtain chlorosulfonated polystyrene. Amidification reaction was then applied to get sulfonamide resin. Sulfonamide resin was treat...