Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in field pain therapy. Thanks to bonding chitosan mucosa and its permeability-enhancing effect, it is excellent choice formulate microspheres for increase drug bioavailability. aim our work includes preparation spray-dried cross-linked non-cross-linked chitosan-based de...

The objective of this study was to formulate and evaluate the drug-polymer interaction of mefenamic acid (MA) using two polymers with different characteristics as ethylcellulose (EC) and/or cellulose acetate phthalate (CAP). Microspheres were prepared by the modified emulsion solvent evaporation (MESE). The effect of drug-polymer interaction was studied for each of microspheres. Important param...

        The purpose of this study was to prepare and characterize microspheres loaded by cyclosporine A(CyA)-cyclodextrin (CD) complex. To achieve this goal, PLGA microspheres loaded by CyA CD complex were prepared by multiple emulsificationsolvent evaporation methods.Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of mi...