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applied serotonin in the cat. Neurology (Minneap) 11: 190—195, 1961 19. Raynor RB, Mcmurtry JG: Prevention of serotonin-produced cerebral vasospasm. An evaluation of blocking agents. J Neurosurg 20: 94—96, 1963 20. Schneck SA, KrichefT II: Intracranial aneurysm rupture, vasospasm, and infarction. Arch Neurol 11: 668-681, 1964 21. Simeone FA, Vinall P: Mechanism of contractile response of cerebr...
High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of the lysosome, an organelle required for autophagy and AMPK, have been associated...
Prostate cancer (PCa) remains the second-leading cause of cancer-related deaths in American men with an estimated mortality of more than 26,000 in 2016 alone. Aggressive and metastatic tumors are treated with androgen deprivation therapies (ADT); however, the tumors acquire resistance and develop into lethal castration resistant prostate cancer (CRPC). With the advent of better therapeutics, th...
The effect of Rainbow trout farms effluents on benthic macro-invertebrates of Marber River in Semirom city was investigated in spring and summer of 2013. Sampling from benthic macro-invertebrates was done monthly using Surber sampler (mouth area of 30.5 * 30.5 cm with a 500 mesh net) at entrance, discharge and far from three fish farms. In addition to measuring physical and chemical parameters ...
Schweiz. Med. Wchns-chr. May 11, 1946. Incidence and significance of infected tonsil remnants. The Eye, Ear, Nose and Throat Mornthly, Vol. XXV, pp. 244-246. May, 1946. RoESSLE.-Ueber Fokalinfektion. Verh. d. deutsch. Gesellsch. f.. Innere Med., Vol. LI, p. 423. 1939. SCHOENBERG, M. J.-Remarks on artificial induction of ocular hypertension by compression of the jugular veins. Arch. Oihthal., Vo...
Organizing textual documents by categorizing them is important and beneficial for information retrieval; but when it comes to clustering documents containing a huge number of terms, the task become challenged. Therefore, selecting effective features is essential for reducing the feature space dimensionality and improving the clustering performances. While numerous methods have been developed fo...
B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by the surface expression of CD20, CD5 antigens, as well as the receptor CD40. Activation of CD40 by its ligand (CD40L) induces proliferation and rescues the cells from spontaneous and chemotherapy-induced apoptosis. CD40 activation also induces secretion of cytokines, such as IL-6, IL-10, TNF-alpha, IL-...
Histone deacetylase inhibitors (HDACi) are a new group of anticancer drugs with tumor selective toxicity. Normal cells are relatively resistant to HDACi-induced cell death compared with cancer cells. Previously, we found that vorinostat induces DNA breaks in normal and transformed cells, which normal but not cancer cells can repair. In this study, we found that checkpoint kinase 1 (Chk1), a com...
losses as well as nitroglycerin and digitalis glycosides were applied with favorable effect to cardiovascular risk patients during the perioperative period.1 3 Frequency of myocardial infarctions and of heart failure during the early postoperative period suggest that in coronary artery disease adrenergic overactivity induces myocardial necrosis and augments the surrounding or preceding "twiligh...
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