''Chacun d'eux portait sur son dos une e ´norme Chimère'' [Each one of them carried on his back an enormous Chimera] —Baudelaire, Le Spleen de Paris, bk. VI Until the end of the seventeenth century, the monstrous body had a mythological function: A sign from irate gods, the monster (Kapler 1980) is not malformed like Oedipus's twisted foot/fate, it is a prodigious creature whose corporeal forma...

BACKGROUND Chimeric CYP21A1P/CYP21A2 genes, caused by homologous recombination between CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) and its highly homologous pseudogene CYP21A1P (cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene), are common in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). A comprehensive juncti...

BACKGROUND Vascular endothelial growth factor-A (VEGF-A) promotes angiogenesis but causes adverse side effects such as edema or tissue inflammation. VEGF-E, found in the genome of the Orf virus, specifically binds to VEGF receptor-2 and shows mitotic activity on endothelial cells. Recently, we created two forms of VEGF-E and human placental growth factor (PlGF) chimera genes (VEGF-E chimera #9 ...

The secreted colonization factor, TcpF, which is produced by Vibrio cholerae 01 and 0139, has generated interest as a potential protective antigen in the development of a subunit vaccine against cholera. This study evaluated immunogenicity/protective efficacy of a TcpF holotoxin-like chimera (TcpF-A2-CTB) following intraperitoneal immunization compared to TcpF alone, a TcpF+CTB mixture, or CTB ...

This is obtained by equating the elements in the first column and first row of the l-matrix with the corresponding element in its product representation obtained by combining any two commensurate 11Z-matrices according to the group property. 6. Ontogenetics. At first appearance, the generalized invariant imbedding relation may seem to have no foundation in the established principles of radiativ...