Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of a cystine knot protein family that includes Cerberus and Gremlin. First isolated in a screen to identify genes down-regulated in transformed rat fibroblasts, DAN has subsequently been cloned in Xenopus, mouse, and human. Overexpression of DAN suppresses the transformed phenotype and retards the cell's entry in...

In this study, a Computational Fluid Dynamics (CFD) model was developed to evaluate ultraviolet disinfection applesauce reactor. To simulate UV reactors, three sets of equations, including hydrodynamics, radiation and species mass conservation were solved simultaneously. The Realizable k-e turbulence model and the discrete ordinate method were used to find the UV radiation profile through the r...

Nup88 is a nuclear pore complex protein which is overexpressed in a variety of human tumors of the stomach, colon, liver, pancreas, breast, lung, ovary, uterus, prostate and kidney. A monoclonal antibody crossreacting with the yeast Candida albicans and Nup88 was used to investigate the expression of cross-reactive antigens in chick embryos, in an attempt to identify an experimental model for s...

BACKGROUND The aim of this study was to develop chick embryo chorioallantoic membrane (CAM) model of laryngeal squamous cell carcinoma (LSCC) and to evaluate the morphological and morphometric characteristics and angiogenic features of it. METHODS Fresh LSCC tissue samples obtained from 6 patients were implanted onto 15 chick embryo CAMs. Morphological, morphometric, and angiogenic changes in...

The production and deposition of extracellular matrix proteins and the cellular origin of type-IV collagen have been analysed immunocytochemically in cocultured or transplanted intestinal epithelial-mesenchymal cell associations. In the first experimental model, rat intestinal endodermal cells were cultured on top of confluent mono-layers of rat intestinal or skin fibroblastic cells. Under thes...

Induction of DNA synthesis in embryonic chick red cells has been examined during the first and second cell cycles after fusion with HeLa cells synchronized in different parts of G1 and S-phase. The data indicate that: (i) the younger the embryonic blood the more rapidly the red cells are induced into DNA synthesis; (ii) the greater the ratio of HeLa to chick nuclei in the heterokaryon, the more...

Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) is a potent activator of cyclic AMP formation in the chick brain. The peptide also stimulates inositol phosphates accumulation and protein kinase C (PKC) activity in the chick cerebral cortex. In this work, we analyzed whether PACAP38-induced increase in cyclic AMP production in the chick cerebrum can be modified by a PKC pathway. ...