A five-year-old male cynomolgus monkey (Macaca fascicularis) with loose stool from two days before dying was observed with dark blood-like watery diarrhea. The animal was not used in the toxicology study as its body weight (4.5 kg) was lower than that of male monkeys of the same age. Gross examination revealed a clockwise rotation of the colon accompanied by a dark-reddish change and distention...

Swarming, a flagellar-driven multicellular form of motility, is associated with bacterial virulence and increased antibiotic resistance. In this work we demonstrate that activation of the SOS response reversibly inhibits swarming motility by preventing the assembly of chemoreceptor-signaling polar arrays. We also show that an increase in the concentration of the RecA protein, generated by SOS s...

Title of Thesis: DEVELOPING TOOLS FOR INVESTIGATING CHEMOTAXIS SIGNAL CLUSTERS IN BACILLUS SUBTILIS James A. Rogers, Jr., Master of Science, 2012 Thesis directed by: Associate Professor Richard C. Stewart Department of Cell Biology and Molecular Genetics Many bacteria make use of a set of dedicated chemoreceptor proteins to control a His-Asp signaling system; this control converts environmental...

Many sensory systems involve multiple steps of signal amplification to produce a significant response. One such mechanism may be the clustering of transmembrane receptors. In bacterial chemotaxis, where a stoichiometric His-Asp phosphorelay from the kinase CheA to the response regulator CheY plays a central role, the chemoreceptors (methyl-accepting chemotaxis proteins) cluster together with Ch...

In this paper, we study the scattering amplitudes of ${D}^{0}{D}^{0}{\ensuremath{\pi}}^{+}\text{\ensuremath{-}}{D}^{*+}{D}^{0}$ coupled channels based on $K$ matrix within Chew-Mandelstam formalism. The ${D}^{0}{D}^{0}{\ensuremath{\pi}}^{+}$ invariant mass spectrum LHCb is fitted, and pole parameters ${T}_{cc}^{+}$ are extracted. analysis behavior suggests that may originate from a ${D}^{*+}{D}...

The goal of understanding mechanisms of transmembrane signaling, one of many key life processes mediated by membrane proteins, has motivated numerous studies of bacterial chemotaxis receptors. Ligand binding to the receptor causes a piston motion of an α helix in the periplasmic and transmembrane domains, but it is unclear how the signal is then propagated through the cytoplasmic domain to cont...

We consider the question: “What is the smallest degree that can be achieved for a plane spanner of a Euclidean graph E?” The best known bound on the degree is 14. We show that E always contains a plane spanner of maximum degree 6 and stretch factor 6. This spanner can be constructed efficiently in linear time given the Triangular Distance Delaunay triangulation introduced by Chew.

The theme of this paper, and the main motivation for writing it, was pro us by Professor Chew Becca, from the Tattooine University, who was visiting Department a few months ago. He presented us with a problem that seemed — to him — of the greatest practical importance. His stay at our Department too brief for us to completely solve the problem, but we are reporting here progress that we have ma...