نتایج جستجو برای: chemoresistance

تعداد نتایج: 5112  

Journal: :International Journal of Biological Sciences 2015

Journal: :Molecular & Cellular Oncology 2018

Journal: :Archives of Medical Science 2021

Introduction Ovarian cancer (OC) frequently occurs in postmenopausal women and it has higher mortality rate. Accumulating researches proved that long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) involved the progression of chemoresistance human OC. Here, study aimed to investigate partial molecular mechanism OC chemoresistance. Material methods The levels NEAT1 microRNA-320b...

Journal: :Cancer research 2006
Lianglin Zhang Jonathan A F Hannay Juehui Liu Parimal Das Maocheng Zhan Theresa Nguyen Daniel J Hicklin Dihua Yu Raphael E Pollock Dina Lev

To better elucidate the role of vascular endothelial growth factor (VEGF)(165) in soft tissue sarcoma (STS) growth, metastasis, and chemoresistance, we generated stably transfected human STS cell lines with VEGF(165) to study the effect of VEGF(165) on STS cells in vitro and the effect of culture medium from these cells on human umbilical vascular endothelial cells. Severe combined immunodefici...

Journal: :Neuro-oncology 2012
Chii-Wen Chou Chi-Chung Wang Chung-Pu Wu Yu-Jung Lin Yu-Chun Lee Ya-Wen Cheng Chia-Hung Hsieh

Tumor cycling hypoxia is now a well-recognized phenomenon in animal and human solid tumors. However, how tumor cycling hypoxia impacts chemotherapy is unclear. In the present study, we explored the impact and the mechanism of cycling hypoxia on tumor microenvironment-mediated chemoresistance. Hoechst 33342 staining and hypoxia-inducible factor-1 (HIF-1) activation labeling together with immunof...

Journal: :Oncology reports 2016
Enjie Xu Jianquan Zhao Jun Ma Ce Wang Chenglin Zhang Heng Jiang Jianyang Cheng Rui Gao Xuhui Zhou

Osteosarcoma is the most common human primary malignant bone tumor and recurrences are common due to the development of chemoresistance. However, the underlying molecular mechanism for chemoresistance remains unclear. Recent studies demonstrated that miR-146b-5p, an important regulator in tumorigenesis, was involved in chemoresistance in thyroid cancer, lymphoma. Thus, to confirm the role of mi...

2016
Shuhei Komatsu Daisuke Ichikawa Tsutomu Kawaguchi Hiroki Takeshita Mahito Miyamae Takuma Ohashi Wataru Okajima Taisuke Imamura Jun Kiuchi Tomohiro Arita Hirotaka Konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Eigo Otsuji

BACKGROUND This study aims to explore novel microRNAs in plasma for predicting chemoresistance in preoperative chemotherapy of patients with esophageal squamous cell carcinoma (ESCC) using a microRNA array-based approach. RESULTS (1) Four candidate microRNAs (miR-223, 103a, 23b and 23a), which were highly expressed in the pretreatment plasma of patients with a low histopathologic response, we...

2012
Giovanni Sette Valentina Salvati Lorenzo Memeo Katia Fecchi Cristina Colarossi Paola Di Matteo Michele Signore Mauro Biffoni Vito D’Andrea Enrico De Antoni Vincenzo Canzonieri Ruggero De Maria Adriana Eramo

BACKGROUND Tumor cells with stem-like phenotype and properties, known as cancer stem cells (CSC), have been identified in most solid tumors and are presumed to be responsible for driving tumor initiation, chemoresistance, relapse, or metastasis. A subpopulation of cells with increased stem-like potential has also been identified within sarcomas. These cells are endowed with increased tumorigeni...

Journal: :Egyptian Liver Journal 2023

Abstract Background Two chief hurdles in most cancer treatments are chemoresistance and tumor recurrence, especially counting hepatocellular carcinoma (HCC). Most conformist chemotherapy fails to completely cure HCC patients because of its susceptibility develop multidrug resistance (MDR) through factors such as hypoxia, stem cells, drug efflux mechanism cells (CSC) which significant involved c...

2011
Laura Rosanò Roberta Cianfrocca Francesca Spinella Valeriana Di Castro Maria Rita Nicotra Alessandro Lucidi Gabriella Ferrandina Pier Giorgio Natali Anna Bagnato

Purpose: Emerging evidence suggests molecular and phenotypic association between chemoresistance and epithelial–mesenchymal transition (EMT) in cancer. Endothelin-1 (ET-1)/endothelin A receptor (ETAR) axis is implicated in the pathobiology of epithelial ovarian cancer (EOC) by driving tumorpromoting effects, including EMT. Here, we analyzed how ETAR regulates chemoresistance and EMT in EOC. Exp...

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