Laulimalide is a potent, structurally unique microtubule-stabilizing agent originally isolated from the marine sponge Cacospongia mycofijiensis. Laulimalide exhibits an activity profile different from other microtubule-binding agents, notably including effectiveness against paclitaxel-resistant cells, but it is intrinsically unstable. Five analogues of laulimalide were designed to exhibit enhan...

Strains of Rhizobium meliloti, Rhizobium sp. nodulating cowpeas, and R. phaseoli derived from cultures susceptible to tetramethylthiuram disulfide (thiram), 2,3-dichloro-1,4-naphthoquinone (phygon), and 2,3,5,6-tetrachloro-p-benzoquinone (spergon), respectively, grew in the presence of high concentrations of the fungicides and converted them to products not toxic to the sensitive rhizobia. The ...

BACKGROUND Investigation of new effective drugs against the methicillin-resistant strains of Staphylococcus aureus (MRSA) is an urgent issue of modern medicine. Antiseptics as an alternative of antibiotics are strong, sustained, and active preparations against resistant strains and do not violate microbiocenosis. MATERIALS AND METHODS The activity of in situ prepared chitosan-Ag nanoparticles...

in carbonate systems, dolomites often form the best reservoirs .the dolomitized part of dalan(upper permian) and kangan(lower triassic) formations makes up the essential part of gas reservoirs in the south of iran. the dalan and kangan formations were dolomitized to various degrees in the areas of south of iran and- persian gulf.in most cases, dolomitization enhanced porosity and permeability o...

Metal nanoparticles have gained significant interest in the past decade because of their unique physio-chemical properties which has a potential to be used in a wide range of applications. Recent efforts have gained success in synthesising nanoparticles with excellent shape and size control; however they are largely restricted to chemical methods. There is an increasing focus on eco-friendly ‘g...

Triatoma infestans (Klug) is the main vector of Chagas disease, which is a public health concern in most Latin American countries. The prevention of Chagas disease is based on the chemical control of the vector using pyrethroid insecticides. In the last decade, different levels of deltamethrin resistance have been detected in certain areas of Argentina and Bolivia. Because of this, alternative ...

Genetic Engineering of a Radiation-Resistant Bacterium for Biodegradation of Mixed Wastes July 25, 2000 Lead Principal Investigator: Prof. Mary E. Lidstrom University of Washington Departments of Chemical Engineering and Microbiology Box 351750 Seattle WA 98195-1750 (206)616-5282 [email protected] Graduate students/post-docs: 3 DOE Problems: above-ground bioremediation treatment systems...

Glucose Oxidation Using Oxygen Resistant Pyranose-2Oxidase for Biofuel Cell Applications Samet Sahin*, Thanyaporn Wongnate, Pimchai Chaiyen, Eileen H. Yu* Newcastle University, School of Chemical Engineering and Advanced Materials, Merz Court, Newcastle upon Tyne, England, NE1 7RU, UK Department of Biochemistry and Center of Excellence in Protein Structure and Function Faculty of Science, Mahid...

Sewage effluent and outfall confluence samples were collected at the Barceloneta Regional Treatment Plant in Barceloneta, Puerto Rico; outfall confluence samples at Ocean City, Md., were also collected. Samples from uncontaminated open ocean areas served as clean-water controls. Bacteria were enriched in marine broth 2216 amended with 1 microgram of one of a set of chemicals selected for study ...

A series of isogenic methicillin-resistant Staphylococcus aureus isolates recovered from a bacteremic patient were shown to acquire gradually increasing levels of resistance to vancomycin during chemotherapy with the drug (K. Sieradzki, T. Leski, L. Borio, J. Dick, and A. Tomasz, J. Clin. Microbiol. 41:1687-1693, 2003). We compared properties of the earliest (parental) vancomycin-susceptible is...