The mechanisms used by Paracoccidioides brasiliensis to survive into phagocytic cells are not clear. Cellular iron metabolism is of critical importance to the growth of several intracellular pathogens whose capacity to multiply in mononuclear phagocytes is dependent on the availability of intracellular iron. Thus, the objective of this paper was to investigate the role of intracellular iron in ...

All patients were treated topically with vitamin K to improve the resolution of laser-induced purpura. In the case of longlasting hyperpigmentation (more than six weeks), the patients were treated with hydroquinone (bleaching cream) and an iron chelator. Complete sun avoidance was recommended for six weeks. Posttreatment compression was unnecessary. Vbeam Pulsed Dye Laser Treatment of Leg Telan...

The extravasation of cytotoxic agents into subcutaneous tissue is a serious complication of chemotherapy. Unfortunately, if such extravasation occurs into the pleural space, limited data is available to guide appropriate management. We present the first report in the literature of video-assisted thoracoscopy combined with a topoisomerase II inhibitor and iron chelator, dexrazoxane, in the succe...

1Children’s Hospital, Harvard University, Boston, MA; 2Università degli Studi di Cagliari, Cagliari, Italy; 3Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Pediatric Haematology, Ege University Hospital, Izmir, Turkey; 5Scienze Cliniche e Biologiche, Torino, Italy; 6Gastroenterology, Children’s Hospital & Research Center Oakland, Oakland, CA; 7Centro della Microcitemia e delle Anemia...

This study compares the biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), an orally active iron chelator, in the normal rat. Surprisingly, CP94 was found to form two phase II metabolites, the 3-O- and 4-O-glucuronides. These glucuronides accounted for 38 and 28% of the administered CP94 dose, in bile and urine, respectively. Unchanged CP94 accounted for 5% of ...

A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

The growth rate of Staphylococcus epidermidis was controlled for populations growing as a biofilm and perfused with supplemented, simple-salts medium. Production of iron chelators, extracellular protease and exopolysaccharide (EPS) by these populations was assessed as a function of specific growth rate and compared to that by planktonic populations grown in the same medium within a chemostat. P...

During preparation of total RNA from Nylanderia pubens (Forel) (Hymenoptera: Formicidae) workers for use in expression library construction, severe RNA degradation consistently occurred. This degradation was masked by spectrophotometric analysis but clearly evident by microfluidic-based assay. Although not specifically identified, the degrading entity was endogenous and localized to the abdomen...

Transfusional iron overload in patients with chronic anemias can result in multiple organ failure. Experience in the management of iron overload in patients with myelodysplastic syndromes is limited, as many do not receive chelation therapy due to short-life expectancy and the difficulties associated with the administration of the current reference standard chelator, deferoxamine. There have, h...

Dear Editor-in-Chief, We shortly report our results of combined iron chelation therapy with deferiprone (DFP) and desferrioxamine (DFX) versus chelation therapy with DFP alone, in iron overloaded β-thalassemia patients. Desferrioxamine has been a life saving iron chelator for thousands of patients in the last 40 years. However, less than 10% of the patients requiring iron chelation therapy worl...