I have always hated Internet chat rooms and studiously avoided them. To me, they are chaotic, confusing, and frustrating. I have also accepted the fact that on this question I am probably in the minority. I suspect that most students who participate in online courses have experience with chat and are quite comfortable with the fragmented and seemingly incoherent conversations that are the hallm...

Comic Chat began as a project at Microsoft Corporation’s new research labs. Our goal was to build a new kind of chat program, that automatically enhanced a textual chat conversation by adding graphics, using conventions adopted from the comics domain. As people type text into Comic Chat, comics panels appear. The program uses traditional comics illustration rules to determine which characters s...

In this article, we propose that adolescents’ online interactions are both a literal and a metaphoric screen for representing major adolescent developmental issues, such as sexuality and identity. Because of the public nature of Internet chat rooms, they provide an open window into the expression of adolescent concerns. Our study utilizes this window to explore how issues of sexuality and ident...

The Modified Checklist for Autism in Toddlers (M-CHAT) questionnaire is a brief measure available in Spanish which needs to be validated for the Mexican population. Parents of children from (1) community with typical development (TD) and (2) psychiatric outpatient unit completed the CBCL/1.5-5 and the Mexican/MM-CHAT-version. The study sample consisted of 456 children (age M = 4.46, SD = 1.12),...

Choline acetyltransferase (ChAT) synthesizes acetylcholine in cholinergic neurons; regulation of its activity or response to physiological stimuli is poorly understood. We show that ChAT is differentially phosphorylated by protein kinase C (PKC) isoforms on four serines (Ser-440, Ser-346, Ser-347, and Ser-476) and one threonine (Thr-255). This phosphorylation is hierarchical, with phosphorylati...

During the adolescent transition from childhood to adulthood, notable maturational changes occur in brain neurotransmitter systems. The cholinergic system is composed of several distinct nuclei that exert neuromodulatory control over cognition, arousal, and reward. Binge drinking and alcohol abuse are common during this stage, which might alter the developmental trajectory of this system leadin...

Decreased Choline Acetyltransferase (ChAT) brain level is one of the main biochemical disorders in Alzheimer's Disease (AD). In rodents, recent data show that the CHAT gene can be regulated by a neural restrictive silencer factor (NRSF). The aim of the present work was to evaluate the gene and protein expression of CHAT and NRSF in frontal, temporal, entorhinal and parietal cortices of AD patie...

Let's talk about the elephant in room. ChatGPT and other Large Language Models (LLM) along with their AI cousins focused on images, graphics, math, coding, audio are dominating our world of generating reports manuscripts. They can be immensely fun: I asked to write me song lyrics fuzzy logic various genres. wasn't crazy folk song, but really liked ChatGPT's blues its bluegrass rendition. And wh...