Objective: To assess the efficacy and tolerability of using high dose Furazolidone just during the first week of two different quadruple regimens in eradicating H. pylori. Methodology: One-hundred sixty patients with duodenal ulcer and positive H. pylori infection were randomly allocated into two groups. Group A received (OAM-F) omeprazole (20 mg BID), amoxicillin (1gr BID), metronidazole (500m...

In this work we introduce the class of graphs with bounded induced distance of order k, (BID(k) for short). A graph G belongs to BID(k) if the distance between any two nodes in every connected induced subgraph of G is at most k times their distance in G. These graphs can model communication networks in which node failures may occur: at a given time, if sender and receiver are still connected, a...

A Matters Arising recently published in Cell by Kaufmann et al. (2007) concludes that the BH3-only Bid protein is dispensable for the DNA damage response. Based on our earlier findings that ATM-mediated Bid phosphorylation is essential for S phase arrest and for the regulation of apoptosis in response to DNA damage (Kamer et al., 2005; Zinkel et al., 2005), we would like to emphasize that we re...

Prior real-world studies have shown that apixaban is associated with a reduced risk of stroke/systemic embolism (stroke/SE) and major bleeding versus warfarin. However, few studies evaluated the effectiveness and safety of apixaban according to its dosage, and most studies contained limited numbers of patients prescribed 2.5 mg twice-daily (BID) apixaban. Using pooled data from 4 American claim...

INTRODUCTION In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intens...

This paper deals with two main issues. First, it takes up a critical stance on the bid to modernize the higher education by resorting to the means provided by the open and distance learning. Then it goes back over the difficulties the implementation of this type of learning encounters within the university environment. Leaving aside the techno-pedagogical aspects so often referred to in order t...

To compare the effect of ritonavir on plasma amprenavir pharmacokinetics, healthy adults received either fosamprenavir (700 mg twice a day [BID]) or amprenavir (600 mg BID) alone and in combination with ritonavir (100 mg BID). Ritonavir increased plasma amprenavir pharmacokinetic parameters to a similar extent when coadministered with either fosamprenavir or amprenavir.

In electronic auction applications, small-value merchandise is often distributed. We call this kind of auction micro auction. Compared to traditional general-purpose electronic auction, micro electronic auction has its own special requirements. Especially, micro auction must be very efficient: the cost of the auction protocol must not be over the cost of the merchandise for sale. Although the m...

Epigenetic mechanisms provide a memory for cells to remember their gene expression pattern and therefore their identity. When this cellular memory fails it can lead to perturbed development or disease. The implications of epigenetic research for human biology and health, including stem cells, cancer and ageing, are far reaching and may be of major importance in the postgenomic era. The new netw...

PURPOSE To determine tolerability, pharmacokinetics, and pharmacodynamics of PD-0325901, a highly potent, selective, oral mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase 1/2 inhibitor in advanced cancer patients. EXPERIMENTAL DESIGN Sixty-six patients received PD-0325901 at doses from 1 mg once daily to 30 mg twice daily (BID). Cycles were 28 days; three ad...