Developing and managing today’s distributed applications is hard. Three importantreasons for the increasing complexity that characterize a large family of systems are:(1) stakeholders involved in the systems have various, often conflicting quality require-ments; (2) the systems are subject to highly dynamic and changing operating condi-tions; (3) activity in the systems is inher...

Introduction During the past 50 years, the transplantation of human organs, tissues, and cells has become a worldwide practice that has extended and greatly enhanced the quality of hundreds of thousands of lives. Transplantation is the best and most cost-effective treatment for end-stage kidney failure and remains the only available treatment for persons with end-stage failure of other solid or...

Evaluation of QOL involves assessments of a wide spectrum of human functioning, including emotional response to cancer and treatment, physical activity, and the impact of the specific cancer on physical and psychological capacities. QOL now constitutes an important part of study for epidemiology, clinical trials, and health services research. From a cancer surveillance perspective, information ...

During the past few years, our understanding of stomatal development and patterning has been advanced by the cloning of a large number of genes in Arabidopsis (Arabidopsis thaliana). These genes encode peptide ligands (epidermal patterning factor, or EPF), and receptor proteins (TOO MANY MOUTHS [TMM] and the ERECTA family [ERf] of receptor-like kinases [ER, ERL1, and ERL2]; Nadeau and Sack, 200...

POLSKIE ARCHIWUM MEDYCYNY WEWNĘTRZNEJ 2016; 126 (12) The information we now have about asthma management, asthma control, and particularly the more acute severe events, exacerbations, hos‐ pital admissions, and so forth, is actually very en‐ couraging. In Ontario, where I work, the risk, for example, of children being admitted to an emer‐ gency room and into a hospital setting for acute severe ...

Almost 20 years ago, Marc Weiser envisioned the prospect of computer in 21st century, and pr o-posed the pioneering notion of ubiquitous computing. One of Weiser’s primary ideas has recently evolvedto a more general paradigm known as context awareness, becoming a central research theme in many otherubiquitous computing programs. From Active Badge considered as the first context -awa...

The passive serum therapy of exper imenta l and clinical tumors, while f requent ly a t t empted , has met with only very l imi ted success (1). The elegant techniques of K~Jhler and Mils tein (2), enab l ing the produc t ion of vi r tual ly un l imi ted amount s of homogeneous an t ibody, have led to a reconsiderat ion of passive an t ibody t r ea tment for ma l ignan t disease. This interest ...

With ever-growing amounts of omics data, the next challenge in biological research is the integration and interpretation of these data to gain mechanistic insights about cellular function. Protein–protein and protein–DNA interaction networks served for over a decade as the workhorses behind those interpretation efforts, but their use was limited to topologically based observations. Specifically...

Clinical medicine is one of the most chal lenging areas for education. The develop ment of clinical competence requires the assimilation of large amounts of knowl edge combined with acquisition of clinical skills and clinical problem-solving ability. Clinical skills include the technical skill in implementing a procedure as well as skill in patient consultation and physical exami nation. Clinic...