Intra-articular instillation of corticosteroids in patients with rheumatoid arthritis (RA) is often followed by transient relief of symptoms and signs of local synovitis (Hollander, Brown, Jessar, and Brown, 1951; Ziff, Scull, Ford, McEwen, and Bunim, 1952). The basis for this clinical improvement is not known and has not been comprehensively correlated with changes in the characteristic synovi...

Systemic lupus erythematosus (SLE) is a chronic disease that is characterized by an undulating course of exacerbations and remissions, and a major determinant of long-term prognosis is organ damage consequent to tissue injury that accompanies disease activity and toxicity of therapy. In this study, we evaluated which patients with SLE will develop an exacerbation and whether factors can be iden...

CASE A 36-year-old man was admitted because of weakness, generalized edema, skin rash, and acute kidney failure with active urine sediment. Results of laboratory studies were as follows: blood leukocyte count, 14× 109/L; hemoglobin, 10 g/dL; blood platelet count, 145 × 109/L; blood urea nitrogen, 102 mg/dL; serum creatinine, 5.8 mg/dL; complement 3, 32 mg/ dL; complement 4, 3 mg/dL; serum hemol...

BACKGROUND Thalassemia is the most common anemia with hereditary base in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgG and complement components in patients with major thalassemia. METHODS This quasi-experimental study (before-after) was performed on 40 patients with major thal...

A 59-year-old man was diagnosed with IgG4-related tubulointerstitial nephritis. His symptoms as well as laboratory and imaging findings were improved after initiation of steroid therapy. Serologically, he showed hypocomplementemia (C3 23 mg/dl, C4 <2 mg/dl, CH50 <7 U/ml) with high levels of IgG (IgG4 1,970 mg/dl) and immune complexes (C1q assay 8.1 μg/ml) and a low level of C1q (<2.0 mg/dl). Hi...

BACKGROUND Live attenuated varicella vaccine is considered a safe vaccine with serious adverse effects reported only in immunocompromised children. We describe a severe life-threatening infection with varicella vaccine virus causing rash and pneumonitis in a 6-year-old boy with no apparent immunodeficiency. METHODS AND RESULTS Polymerase chain reaction (PCR) analysis of vesicle swab samples d...

BACKGROUND & OBJECTIVES Results of earlier studies to evaluate the possible role of complement system in tropical pulmonary eosinophilia (TPE) using classical methods like serum haemolyte component CH50, C3 and C4 levels were inconclusive. In this study we determined levels of serum C3d which is a catabolic fragment of C3, to find out any direct evidence of activation of the complement system i...

The paper describes sterically stabilized lipid nanocapsules (LNC) and multilamellar liposomes (MLV) coated using a new amphiphilic conjugate of PEG(2000) with a 2-alkyl-lipoamino acid (LAA). A complement activation assay (CH50) and uptake experiments by THP-1 macrophage cells were used to assess in vitro the effectiveness of the PEG-LAA derivative of modifying the surface behavior of nanocarri...

Objective To report the study design of a Phase 2, multicenter, randomized, placebo controlled, parallel-group (ARDA, NCT05225675 ) will assess safety, efficacy, PK, and PD ARGX-117 in adults with MMN. Background Multifocal motor neuropathy (MMN) is chronic, immune-mediated characterized by progressive asymmetric weakness predominantly affecting distal upper limbs. MMN often associated anti-GM1...

Atypical hemolytic syndrome (aHUS) is a rare renal disease. It has been recognized to be due genetic mutations in more than 60 % of cases. Its pathogenesis characterized secondary Alternative complement pathway dysregulation. We aim report the genotypic and phenotypic features homozygous mutation C3 gene three infants different families from same tripe. will go through their early sever present...