In this issue of Blood, Flynn et al1 provide key data that lend further support to the development of clinical trials of spleen tyrosine kinase (Syk) inhibition for more effective chronic graft-versus-host disease (cGVHD) treatment.

Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown t...

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is life-saving for severe hematological conditions. However, its outcomes need further improvement, and co-infusion of mesenchymal cells (MSCs) may show promise. A growing body research on this subject exists, while the results different trials are conflicting. systematic review meta-analysis needed to appraise r...

Background Keratoconjunctivitis sicca from chronic graft-versus-host disease (cgvhd) after allogeneic stem cell transplantation is common, leading to severe corneal damage and blindness if not treated. We retrospectively examined the efficacy and safety of pooled human albumin eye drops (haeds) for symptom relief in 40 stem-cell transplantation patients after other alternatives had failed. Meth...

Hematopoietic stem-cell transplantation using cells obtained from peripheral blood, bone marrow, or cord blood is being used to treat not only genetic and immunologic diseases, but also a variety of hematologic malignancies. Significant advances have been made in the management of such procedures, leading to improved rates of engraftment, prognosis, and quality of life, but graft-versus-host di...

One of the main of concerns in allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the profound and long-lasting immunodeficiency leaving patients highly susceptible to multiple infections. Accordingly, a low B-cell recovery after allo-HSCT has been associated with high infection rate. B-cell reconstitution is a slow process characterized by a relative increase of the percentage o...

www.cmj.hr Aim To investigate the ability of two standard quality of life (QOL) questionnaires – The Short Form (36-item) Health Survey (SF-36) and The European Organisation for Research and Treatment of Cancer Quality of Life QuestionnaireCore 30 (EORTC QLQ C30) to evaluate QOL in patients with chronic graft-vs-host disease (cGVHD) graded according to National Institutes of Health (NIH) consen...

PURPOSE Two new drugs with mucin-inducing and secretion-promotive effects, rebamipide and diquafosol, were recently approved as topical dry-eye treatments. We report two cases in which the long-term use of mucin-inducing eye drops improved chronic ocular graft-versus-host disease (cGVHD)-related dry eye and ocular cicatricial pemphigoid (OCP)-like disease. CASE REPORTS Case 1. A 61-year-old w...