Calcitonin gene-related peptide (CGRP) is a potent vasodilator and relaxes smooth muscle of a variety of tissues, but the effects of CGRP on human myometrial contractions and the changes in CGRP receptors (CGRP-Rs) in human myometrium have not been described. We report that CGRP induced dose-dependent relaxation in spontaneously contracting myometrium from pregnant women. This relaxation effect...

Background : The purpose of this study was to examine the influence of combined training program on C-reactive protein (CRP) serum and interleukin-6 (IL-6) plasma concentrations in sedentary men. Materials and Methods: In this quasi-experimental study, twenty sedentary men (23±2 years) volunteers (with no history of regular exercise program, weight deviation more than 2 kg, special disease and...

Overexpression of calcitonin gene-related peptide (CGRP), an extremely potent vasodilator, to blood vessels is a possible strategy for prevention of vasospasm. We constructed an adenoviral vector that encodes prepro-CGRP (Adprepro-CGRP) and examined the effects of gene transfer on cultured cells and cerebral arteries. Transfection of Adprepro-CGRP to Cos-7 and NIH-3T3 cells increased CGRP-like ...

Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded that: (i) CGRP may have an important role in migraine pathophysiology, and (ii) inhibition...

in order to estimate the genetic parameters and comparison legendre polynomials for production traits of iranian holstein dairy cattle test-day records of first lactation cows for milk yield, fat yield, protein yield, fat percentage and protein percentage traits were used. these records collected from 2006 to 2010, by the animal breeding center of iran. the genetic parameters were estimated usi...

Cluster of differentiation 4 gene (CD4) is well known for its role in immunity, but its effects on production traits remain to be elucidated. The present study was designed to explore single nucleotide polymorphisms (SNPs) in the exons, flanking introns, and promoter of CD4, as well as to analyze their effects on milk production traits (percentage of protein, fat, and lactose; mastitis indicato...

BACKGROUND Visceral fat is related to coronary atherosclerosis, but little is known about the relation between coronary atherosclerosis and percent body fat accumulated in different parts of the body. METHODS AND RESULTS The subjects were 100 consecutive patients with demonstrated electrocardiographic ischemic changes. Coronary atherosclerosis was assessed using Gensini's coronary score (CS),...

Excess of body fat often leads to obesity. Obesity is typically associated with serious medical diseases, such as cancer, heart disease, and diabetes. Accordingly, knowing the body fat is an extremely important issue since it affects everyone's health. Although there are several ways to measure the body fat percentage (BFP), the accurate methods are often associated with hassle and/or high cost...

Anthropometry is a simple and cost-efficient method for the assessment of body composition. However prediction equations to estimate body composition using anthropometry should be 'population-specific'. Most popular body composition prediction equations for Japanese females were proposed more than 40 years ago and there is some concern regarding their usefulness in Japanese females living today...